实验性面神经再生过程中轴浆转运的变化  

Changes of axoplasmic transportation during experimental facial nerve regeneration

作　　者：马宏敏[1] 王锦玲[1] 邱建华[1] 黄维国[1] 

机构地区：[1]第四军医大学西京医院耳鼻咽喉科,西安710032

出　　处：《临床耳鼻咽喉科杂志》2002年第11期610-612,共3页Journal of Clinical Otorhinolaryngology

基　　金：国家自然科学基金资助项目(No.39370731)

摘　　要：目的:研究轴浆转运在面神经损伤再生过程中的变化及其作用。方法:利用豚鼠面神经损伤模型,面神经核内微量注射标记蛋白前体结合闪烁计数技术测量豚鼠面神经损伤后不同时段的放射活性。结果:面神经损伤后3 d再生神经远端轴浆转运再现,14 d转运功能基本恢复,21 d再生轴突中标记蛋白的转运波形与正常对照相似;慢转运波型出现特有的W1波和W2波;利用快、慢转运标记蛋白测得的面神经平均再生速度分别为(2.84±0.12)mm/d和(3.16±0.08)mm/d。结论:轴浆转运功能在神经再生中起着重要的作用。Objective;To determine the roles of axoplasmic transportation during regeneration after facial nerve injury. Method: Facial ncleus injection and isotopic-label tracer with liquid scintillation counting techniques were used to investigate the changes of radioactivity after guinea pig facial nerve compressed. Result: Axoplasmic transportation was observed again at 3 d after facial nerve injury,and the function recovered until 14 d. At 21 d after injury, it showed that transportation curve of radiolabeled protein was smillar with that of the normal. There was particular curve in slow axoplasmic transportation that included two wave:Wl and W2. The axons regerated at a rate of (2. 84?. 12)mm/d in fast transportation while that of slow transportation is (3. 16 + 0. 08)mm/d. Conclusion: It suggests that axoplasmic transport act as a important role during the course of facial nerve regeneration.

关 键 词：面神经损伤 轴浆转运 神经再生 

分 类 号：R745.12[医药卫生—神经病学与精神病学]