TACE加^(32)P-GMS治疗中晚期肝癌疗效分析  

CLINICAL ANALYSIS OF TACE PLUS ^(32)P-GMS IN ADVANCED HEPATIC CARCINOMA

作　　者：杜伟[1] 林世杰[1] 罗开元[1] 时德[2] 张庆丰[1] 

机构地区：[1]云南省第二人民医院,昆明650021 [2]重庆医科大学第一附属医院,重庆400016

出　　处：《肝胆外科杂志》2002年第5期351-352,共2页Journal of Hepatobiliary Surgery

摘　　要：目的　探讨肝动脉化疗栓塞 (TACE)加 32 磷—玻璃微球 (32 P- GMS)内照射治疗中晚期肝癌的治疗效果。方法　随机选择 4 8例中晚期肝癌患者分为两组 ,其中 2 3例 (A组 )采用 TACE加 32 P- GMS内放射进行治疗 ;另 2 5例 (B组 )为同期肝动脉化疗栓塞治疗患者 ,做为对照组。两组患者在年龄均数、肿瘤直径以及肿瘤转移率等方面均具有较好的可比性 (P>0 .0 5 )。最后比较两组的治疗效果以及累计生存率。结果　治疗后 3月观察 A组病灶缩小 >5 0 % 5例 ,缩小 <5 0 % 8例 ,有效率为5 6 .5 2 % (13/ 2 3) ,B组 2 8例中有效 9例 (36 % ) ,经 Ridit分析 ,两组有显著性差异 (P<0 .0 5 )。 6个月、12个月、2 4个月 A组生存率分别为 86 .96 %、4 7.83%、2 1.74 % ,而对照组分别为 5 2 %、16 %、0 .0 0 % (P<0 .0 5 )。结论　 TACE加 32 P-Objective To explore the treatment of trascatheter arterial chemoembolization(TACE)plus 32 P glass microspheres for advanced hepatic carcinoma.Methods 48 patients were devided into two group:group a treated by TACE+ 32 P GMS(n=32),and group B by TACE simultaneosly as controls.The average age,diameter of tumor and rate of metastasis were similar with two groups(P>0.05).Results The rates of reduction in tumor diameter in group A was 56.52%(13/23),while those of group B was 36%(9/25).There was significant differency between the two groups(P<0.05).The 6 moth?12 moth?24 moth survival rates of group A were 86.96%?47.83%?21.73%,respectively,In contrast,those data in group B were 52%?16%?0.00%,respectively(P<0.05). Conclusion TACE plus 32 P GMS is one of the efficient method for hepatic carcinoma.

关 键 词：TACE ^32P-GMS 治疗 中晚期肝癌 疗效分析 

分 类 号：R735.7[医药卫生—肿瘤] R730.5[医药卫生—临床医学]