多项生物学指标在乳腺癌中的表达及其关系与预后  

The Expression and Correlation of Multiple Tumor Biomarkers and Their Prognostic Predictive Value

作　　者：陈亦欣[1] 王秀清[1] 徐敏[1] 许瑞莲[1] 白桦[1] 叶建增[1] 陈伟[1] 

机构地区：[1]暨南大学第二附属医院肿瘤研究所,深圳518020

出　　处：《现代临床医学生物工程学杂志》2002年第5期370-372,共3页Journal of Modern Clinical Medical Bioengineering

摘　　要：目的　探讨多项生物学指标c-erbB - 2、PCNA、P5 3、EGFR、nm2 3、ER、PR在乳腺癌中的表达与临床乳腺癌预后的关系及这些指标间的相互关系 .方法　应用免疫组织化学方法对 87例乳腺癌组织切片c -erbB - 2、PCNA、P5 3、EGFR、nm2 3、ER、PR的表达进行检测 .结果　乳腺癌远处转移率与腋淋巴结转移数目有关 ,c -erbB - 2阳性率与肿瘤大小、临床分期正相关 ,PCNA阳性率与肿瘤大小、腋淋巴结转移数目正相关 ,P5 3与肿瘤大小正相关 ,c -erbB - 2与PCNA、P5 3、EGFR、PR相关 ,P5 3与PR相关 ,ER与PR相关 .结论　肿瘤大小、腋淋巴结转移数目、临床分期、c -erbB- 2、PCNA、P5 3。Objective To detect the expression of multiple tumor biomarkers in breast cancer, and to evaluate the prognostic and predictive uses and correlation among these biomarkers. Methods Expression of 7 biomarkers: c-erbB-2?PCNA?P53?EGFR?nm23?ER?PR in 87 breast cancer patients were determined by immunohistochemistry. Logistic regression and chi-square test were used for analysis. Results Distant metastasis was positively related with metastasized axillary lymph node number;C-erbB-2 was associated with tumor diameter?clinical stage?PCNA?P53?EGFR and PR;P53 was associated with tumor diameter and PR; PCNA was positively related with tumor diameter and metastasized axillary lymph node number;ER was linked with PR. Conclusions Multiple clinical and biological indicators such as tumor diameter?axillary lymph node metastasis?clinical stage?c-erbB-2?P53?PCNA?PR are helpful for enhancing the predictive accuracy of prognosis in breast cancer.

关 键 词：生物学指标 乳腺癌 预后 相互关系 

分 类 号：R737.9[医药卫生—肿瘤]