Diterpenoids from Isodon sculponeatus  

作　　者：姜北 梅双喜 赵爱华 孙汉董 吕扬 郑启泰 

出　　处：《Chinese Journal of Chemistry》2002年第9期887-890,共4页中国化学（英文版）

摘　　要：b Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China c Pharmaceutical Department of Dali College, Dali, Yunnan 671000, China Further investigation on the leaves of Isodon sculponeatus afforded two new ent kaurane diterpenoids, sculponeatins J and K . Their structures were elucidated on the basis of their spectral properties, as well as X ray crystallographic analysis. The cytotoxicities of these two new compounds against human tumor cells K562 and T24 were also tested, and sculponeatin J showed significant inhibitory effects with IC 50 values less than 1.0 μg/mL.b Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China c Pharmaceutical Department of Dali College, Dali, Yunnan 671000, China Further investigation on the leaves of Isodon sculponeatus afforded two new ent kaurane diterpenoids, sculponeatins J and K . Their structures were elucidated on the basis of their spectral properties, as well as X ray crystallographic analysis. The cytotoxicities of these two new compounds against human tumor cells K562 and T24 were also tested, and sculponeatin J showed significant inhibitory effects with IC 50 values less than 1.0 μg/mL.

关 键 词：Isodon sculponeatus LABIATAE ent    kauranoid sculponeatins J   and   K CYTOTOXICITY 

分 类 号：O657.3[理学—分析化学]