酒依赖相关精神障碍患者的脑干听觉反应及P_(300)异常变化  

Auditory brainstem response and event related potential P_(300) in patients with alcoholism

作　　者：王祖承[1] 徐鹤定[1] 徐筠[1] 朱敏捷[1] 胡莺燕[1] 倪晓东[1] 李妍[1] 陈兴时[1] 

机构地区：[1]上海市精神卫生中心,200030

出　　处：《中华精神科杂志》2002年第4期231-233,共3页Chinese Journal of Psychiatry

摘　　要：目的　探讨酒依赖患者脑干听觉反应 (ABR)及P30 0 的特点。方法　以click短声、听觉靶刺激和非靶刺激为诱发事件 ,检测 2 6例男性酒依赖患者及 31名男性正常人的ABR和事件相关电位P30 0 。结果　 (1 )ABR :与对照组比较 ,酒依赖组波Ⅱ～波Ⅶ的绝对潜伏期长 ,波Ⅱ～波Ⅴ的绝对波幅低 ,差异均有显著性和非常显著性 (P <0 0 5或P <0 0 1 ) ;(2 )P30 0 :在靶刺激中 ,酒依赖组的P2 和P3潜伏期 [分别为 (1 87± 2 6)ms和 (31 9± 2 7)ms]长于对照组 [分别为 (1 71± 2 1 )ms和 (30 2± 1 6)ms] ,P2 和P3波幅 [分别为 (3 9± 2 3) μV和 (3 5± 3 1 ) μV]低于对照组 [分别为 (6 0± 2 1 ) μV和 (8 2± 4 1 ) μV] ;在非靶刺激中 ,酒依赖组的N1 潜伏期 [(1 0 8± 1 4 )ms]长于对照组 [(98± 1 2 )ms] ;差异有显著性和非常显著性 (P <0 0 5或P <0 0 1 )。结论　长期大量饮酒不仅损害脑干功能 。Objective This study was conducted to investigate the characteristics of auditory brainstem response (ABR) and event related potential P 300 of patients with alcoholism Methods Both ABR and P 300 were recorded from 26 male alcoholics and 31 normally male controls Results The alcoholic patients showed abnormally irregular ABR and P 300 wave forms compared with the controls ABR in patients showed delayed absolute latencies (waves Ⅱ Ⅶ) and decreased amplitudes (wave Ⅱ, wave Ⅲ, wave Ⅳand wave Ⅴ; P <0 05 or P <0 01) Both target P 300 and nontarget P 300 in patients presented prolonged latencies and decreased amplitudes of major components ( P <0 05 or P <0 01) Conclusion Long term and large amount alcohol drinking damages not only the cognitive function but also the brainstem function The combination of P 300 and ABR is more efficient in detecting the brain function of alcoholics

关 键 词：酒依赖相关精神障碍 脑干听觉反应 P300异常 ABR 

分 类 号：R749.62[医药卫生—神经病学与精神病学]