难治性精神分裂症立体定向手术治疗前后认知功能的对照  

Study of cognitive function in stereotactic surgery to schizophrenics

作　　者：杨来启[1] 王晓峰[1] 李栓德[1] 胡淑芳[1] 吴兴曲[1] 刘光雄[1] 马文涛[1] 姜克明[1] 宋世田[1] 张红宾[1] 李涛[1] 

机构地区：[1]解放军第三医院兰州军区精神卫生中心,陕西宝鸡721004

出　　处：《第四军医大学学报》2002年第21期2010-2012,共3页Journal of the Fourth Military Medical University

基　　金：全军临床高新技术重大项目 ;全军医学科研"十五"计划面上项目 A类 (0 1MA0 19)

摘　　要：目的　应用现代立体定向手术治疗部分难治性精神分裂症 5 0例 ,探讨立体定向手术对难治性精神分裂症的认知功能的改善及临床疗效 .方法　采用威氏康星卡片分类测验 (WCST)、韦氏成人智力测定量表观察认知功能的变化 .选用简明精神病评定量表 (BPRS) ,阳性与阴性症状量表(PANSS) ,临床疗效总评量表 (CGI)评定疗效 .由两名精神科医生手术前后评定 ,统一标准 ,评定时间分别在手术前 2 d和出院前 ,手术后 1,3和 6 mo.结果　手术后 WCST的总测验次数、持续错误数、非持续错误数均低于手术前 ,具有显著性差异 ,手术后韦氏成人智力测定智商无减低 .临床疗效 :临床治愈 2例 ,显效 32例 ,有效 14例 ,无效 2例 ,总有效率为96 % .结论　现代立体定向手术治疗难治性精神分裂症是一种疗效明显 ,能改善认知功能的方法 .AIM To investigate the amelioration of cognitive function and clinical effect on refractory schizophrenics after the stereotactic operation. METHODS The changes of cognitive function were observed with WCST and WICS. The clinical effect was evaluated with BPRS, PANSS and CGI. RESULTS Compared with preoperative, good performance on the WCST of total trials of category (TT), perseverative errors (PE) and nonperseverative errors (NPE) were found in post operation. The marks of VIQ, PIQ, MQ, FIQ in the WICS were higher in post operation than that in per operative. 2 schizophrenics were cured. Thirty two schizophrenics were in apparent effection. Fourteen schizophrenics were effective. Two schizophrenics were inefficiency. CONCLUSION The stereotactic technique is a good method which can improve cognitive function of refractory schizophrenics.

关 键 词：精神分裂症 立体定向 手术治疗 认知功能 多靶点 

分 类 号：R749.3[医药卫生—神经病学与精神病学]