N-(3′,4′,5′,-三甲氧基肉桂酰)邻氨基苯甲酸的抗过敏作用研究  

ANTIALLERGIC EFFECTS OF N-(3',4',5'-TRIMETHOXYCINNAMOYL) ORTHO-AMINOBENZOIC ACID

作　　者：斯拉甫[1] 马俊江[1] 丁瑛[1] 凌仰之[2] 林志彬[1] 

机构地区：[1]北京医科大学药理学教研室 [2]北京医科大学药学院药物化学教研室

出　　处：《北京医科大学学报》1992年第6期452-454,共3页Journal of Peking University(Health Sciences)

摘　　要：N-(3’,4’,5’-三甲氧基肉桂酰)邻氨基苯甲酸(TOA)(100 mg·km^(-1)ip)显著抑制同系大鼠被动皮肤过敏反应(PCA)。剂量为 50和100 mg·kg^(-1)·d^(-1),ip×4d时,明显抑制大鼠反相皮肤过敏反应(RCA)。致敏同时给药(50和100mg kg^(-1)·d^(-1),ip×6d)或攻击前给药(100mg·kg^(-1)·d^(-1),ip×2d),TOA对SRBC诱导的小鼠迟发型过敏反应(DTH)均有明显抑制作用。剂量为 50和100 mg·kg^(-1)ip时,TOA对大鼠皮内注时组胺及5-羟色胺(5-HT)引起的毛细血管通透性增加均有显著拮抗作用。Antiallergic effects of N-(3',4',5'-Trimethoxy cinnamoyl)Ortho-aminobenzoic acid(TOA)were stu-died in rats and mice. TOA(100mg. kg^(-1). ip) inhibited 48h homologous passive cutaneous anaphylaxis(PCA) in rats. At the Dose of 50 or 100mg.kg^(-1), ip for 4 or 6 days, TOA also significantly inhibi-ted reversed cutaneous anaphylaxis(RCA)in rats. and delayed type hypersinsitivity(DTH) to sheep redblood cells(SRBC)in normal mice. The studies also showed that TOA can markedly decrease the capil-lary permeability induced by histamine and 5-HT. The reslults indicate that it may be valuable to de-velop TOA as an antiallergic drug.

关 键 词：肉桂酰胺类 抗过敏 药理学 

分 类 号：R965.2[医药卫生—药理学]