胃肠道低分化恶性肿瘤临床病理及免疫组化研究  

A Clinicopathologic and Immunohistochemical Study on Poorly Differentiated Malignant Tumors in Gastrointestinal Tract

作　　者：黄爱民[1] 高凌云[1] 翁景萱[1] 

机构地区：[1]福建医科大学基础医学院病理学系,福建福州350004

出　　处：《中国误诊学杂志》2002年第10期1444-1446,共3页Chinese Journal of Misdiagnostics

摘　　要：目的　探讨胃肠道低分化恶性肿瘤的诊断与鉴别诊断 ,提高诊断准确率。方法　对 63例胃肠道低分化恶性肿瘤进行五种抗血清的免疫组化标记 ,部分病例行电镜检查。结果　原病理诊断为未分化癌者 2 5%应修正诊断为恶性淋巴瘤 ;原病理诊断为恶性淋巴瘤的病例 ,1 6.7%应修正诊断为未分化癌 ;原诊断恶性肿瘤来源难定的病例 52 %为未分化癌 ,36%证实为恶性淋巴瘤 ,4%考虑为低分化平滑肌肉瘤。结论　联合应用多个指标的免疫组化标记并辅以电镜超微结构观察 ,可明显提高胃肠道低分化恶性肿瘤的诊断准确率 ,对于治疗方案的制定及患者预后的估计具有重要的临床指导意义。Objective To explore the pathological diagnosis and differential diagnosis of poorly differentiated malignant tumors in gastrointestinal tract.Methods Immunohistochemical stainning on five antibodies were performed in 63 cases of poorly differentiated gastrointestinal malignant tumors,and electron microscopy was used in some of the cases.Results 25% cases originally pathologically diagnosed as undifferentiated carcinoma should be revised to Non Hodgkin's Lymphoma(NH L);whereas 16.7% cases originally diagnosed as NHL should be revised to undifferentiated carcinoma.In the 25 cases of malignancy with type unclassified, 52% was undifferentiated carcinoma,and 36% was confirmed as NHL,4% was poorly differentiated leiomyosarcoma.Conclusion It was very helpful and practical by using immunohistochemical technique for the differential diagnosis between NHL and poorly differentiated or undifferentiated carcinoma in gastrointestinal tract,which could be of benefit to the treatment scheme formulation and the prognosis evaluation.

关 键 词：病理学 免疫组织化学 胃肠道 低分化恶性肿瘤 鉴别诊断 

分 类 号：R735[医药卫生—肿瘤] R730.23[医药卫生—临床医学]