C-erbB-2在LN(-)乳腺癌中的表达及其意义  

RELATIONSHIP BETWEEN EXPRESSION OF C-erbB-2 PROTEIN IN LN(-) BREAST CANCER WITH PROGNOSIS

作　　者：王睿敏[1] 张爱武[2] 成平 张晓云[1] 马激扬[1] 

机构地区：[1]内蒙古医学院第一附属医院普外科,内蒙古呼和浩特010050 [2]内蒙古医学院第一附属医院药剂部 [3]山东文登中心医院,山东文登264400

出　　处：《内蒙古医学院学报》2002年第3期145-147,172,共4页Acta Academiae Medicinae Neimongol

摘　　要：目的 :研究 C-erb B-2在 LN(-)乳腺癌中的表达对判断预后的意义。方法 :1 0 a内随访 LN(-)乳腺癌病人 49例 ,用链霉素生物蛋白 -过氧化物酶免疫组化染色法 (S-P法 )测定石蜡标本中 C-erb B-2的表达 ,结合临床和病理资料分析其作用。结果 :49例 LN(-)乳腺癌中 ,2 3例 C-erb B-2阳性 ,阳性率 46.93 % ,C-erb B-2阳性表达与无瘤生存率、5 a生存率、总生存率有关 (P <0 .0 5 ) ,与局部复发、远处转移有关 (P <0 .0 5 )。结论 :C-erb B-2阳性的乳腺癌病人预后差 ,易转移、易复发 ,总生存率、5 a生存率、无瘤生存率均低 ,因此 LN(-)乳腺癌病人测定 C-erb B-2对临床制定治疗方案和判定预后有重要意义。Objective: To study the C-erbB-2 protein expression in LN(-) breast cancer, and analyze the relationship between its expression and prognosis of breast cancer. Methods: By means of immunohistochemical S-P method, 49 none of lymph node metastasis breast cancer specimens in praraffin sections were examined for the expression of C-erbB-2. Results: 23 out of 49 casesof breast cancer showed over-expression C-erbB-2 with a positive rate of 46.93%. The over expression of C-erbB-2 was correlated with regional recurrence,distant metastasis, lower total survival ,lower 5 years survival.and free survival. Conclusion: LN(-) patient with overexpression of C-erbB-2 may be used for predicting the prognosis of breast cancer.\;

关 键 词：C-ERBB-2 乳腺癌 预后 免疫组化SP法 基因表达 

分 类 号：R737.9[医药卫生—肿瘤]