海洛因成瘾者姐妹染色单体交换频率的观察研究  

A STUDY OF SISTER CHROMATID EXCHANGE(SCE) IN DRUG ADDICTS

作　　者：韩艳秋[1] 王志纲[2] 李杰[3] 刘桂荣[3] 

机构地区：[1]内蒙古医学院第一附属医院内科,内蒙古呼和浩特010050 [2]内蒙古精神卫生中心 [3]内蒙古医学院生物教研室

出　　处：《内蒙古医学院学报》2002年第3期168-169,共2页Acta Academiae Medicinae Neimongol

摘　　要：目的 :检测海洛因成瘾者的 DNA损伤程度。方法 :采用外周血淋巴细胞姐妹染色单体差别染色法检测技术 ,观察了 3 3例海洛因成瘾者的姐妹染色单体交换 (SCE)频率 ,同时检测 3 0名健康者进行对照。结果 :海洛因成瘾者的 SCE频率明显高于正常对照值 ,P <0 .0 1 ;海洛因成瘾者男性和女性的 SCE频率无差异 ,P >0 .0 5。结论 :海洛因可增加人体的 DNA损伤 ,人类应该远离毒品。objective: To detect damage degree of DNA in heroin abuse. Methods: The sister chromatid exchanges(SCE) frequency were counted in the sample of 33 patients with SCE different stain method, in the same time, we detected 30 normal controls. Results: The SCE frequency of lymphocytes in patients was higher than that of the controls, P<0.01. Conclusion: Heroin is able to increase the damage degree of DNA of the human body, people should go away from drugs.\;

关 键 词：海洛因成瘾 姐妹染色单体交换 细胞遗传学 

分 类 号：R749.6[医药卫生—神经病学与精神病学] R394.[医药卫生—临床医学]