血清LDH、TPS、CEA和β2-MG在非霍奇金淋巴瘤诊断中的价值  

Value of serum LDH,TPS,CEA and β2-MG in the diagnosis of non-Hodgkin's lymphoma

作　　者：陈维[1] 魏涛[1] 

机构地区：[1]广州市花都区人民医院肿瘤科,广东广州510800

出　　处：《分子影像学杂志》2015年第3期257-259,共3页Journal of Molecular Imaging

摘　　要：目的研究血清乳酸脱氢酶(LDH)、组织多肽特异性抗原(TPS)、癌胚抗原(CEA)和β2-微球蛋白(β2-MG)在非霍奇金淋巴瘤(NHL)诊断中的价值。方法分别采用速率法和酶联免疫吸附法测定62例NHL患者、8例淋巴结良性病患者及40例健康体检者血清LDH、TPS、CEA和β2-MG水平。结果(1)NHL组血清LDH、TPS、CEA和β2-MG水平明显升高,与淋巴结良性病组和健康体检组比较差异有统计学意义(P<0.05);淋巴结良性病组和健康体检组比较,四种肿瘤标志物水平差异无统计学意义(P>0.05);(2)血清LDH、TPS、CEA和β2-MG水平在NHL中的高度恶性组、中度恶性组、低度恶性组之间差异无统计学意义(P>0.05)。结论血清肿瘤标志物LDH、TPS、CEA和β2-MG的检测,对NHL的诊断具有重要参考价值。Objective To explore the clinical value of serum lactic dehydrogenate(LDH),tissue polypeptide specific antigen(TPS),carcinoembryonic antigen(CEA),andβ2-microglobulin(β2-MG) in the diagnosis of non-Hodgkin,s lymphoma(NHL).Methods The serum level of LDH was determined with automatic biochemical analyzer and TPS,CEA and β2-MG levels were determined by enzyme-linked immumosorbent assay(ELISA) in 62 NHL patients,8 lymphatic neagative patients and 40 healthy persons.Results(1)The serum levels of LDH、TPS、CEA and β2-MG in NHL patients were higher than other groups(P<0.05);(2)There was no statistical significance in examining the serum levels of LDH、TPS、CEA and β2-MG in NHL patients in high malignancy group,middle malignancy group and low malignancy group(P>0.05).Conclusion The detection of serum LDH、TPS、CEA and β2-MG is of value in diagnosis in patients with NHL.

关 键 词：非霍奇金淋巴瘤 乳酸脱氢酶 组织多肽特异性抗原 癌胚抗原 β2-微球蛋白 

分 类 号：R733.1[医药卫生—肿瘤]