血浆置换治疗5例海洛因海绵状白质脑病的临床分析  

Clinical analysis of the treatment on heroin spongiform leukoencephalopathy by plasma exchange in 5 cases

作　　者：史东葵[1] 吴科研[1] 成桂明[1] 

机构地区：[1]武警广东省总队医院内五科,广东广州510507

出　　处：《分子影像学杂志》2015年第4期386-387,共2页Journal of Molecular Imaging

摘　　要：目的分析海洛因海绵状白质脑病(HSLE)的临床特点和诊断治疗情况。方法对5例HSLE患者的临床症状、影像学及血浆置换治疗进行分析。结果 3例临床症状改善,1例无变化,1例死亡。结论 HSLE患者均有海洛因吸食或静脉注射史,临床主要表现一系列神经系统症状,影像学显示受累部位多位于双侧小脑半球,脑干桥脑、中脑,丘脑、内囊后肢,额颞叶,枕顶叶,皮层下白质和脑室周围白质,胼胝体压部、血浆置换(PE)可能有效。Objective To analyze the clinical characteristics and diagnosis and treatments of heroin spongiform leukoencephalopathy(HSLE). Methods the clinical symptoms, imaging and plasma exchanges in 5 patients with HSLE were analyzed. Results the clinical symptoms of 3 cases had improved, while 1 case had no change and 1 case died. Conclusion All of HSLE patients had history of snorting or intravenous injection of heroin. The main clinical manifestations of them are a series of nervous system symptoms. Moreover imaging of them shows the involved sites were mostly located in the cerebellum hemispheres, brainstem, thalamus, the posterior limb of the internal capsule, white matter of subcortex and surrounding ventricle and the splenium of corpus callosum. Therefore, plasma exchange(PE) may be effective.

关 键 词：海洛因海绵状白质脑病 血浆置换 临床 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]