5′-差向庆大霉素C1a及其衍生物的合成及生物活性的研究  

Synthesis and biological activities of 5′-epi-gentamicin C1a and its derivatives

作　　者：郑卫[1] 卓锦明[1] 张俊成[1] 张发香[1] 程元荣[1] 

机构地区：[1]福建省微生物研究所,福州350007

出　　处：《中国抗生素杂志》2002年第10期592-595,共4页Chinese Journal of Antibiotics

摘　　要：以西索米星、奈替米星为母核 ,对双键进行选择催化氢化 ,得到氢化西索米星 ( 5′ 差向庆大霉素C1a)和新化合物氢化奈替米星 ( 5′ 差向依替米星 ) ,由于它们的空间构象发生改变导致抗菌活性的降低。Hydrosisomicin (5′-epi-gentamicin C1a) and hydronetilmicin (5′-epi-etimicin) were synthesized from sisomicin and netilmicin by selective catalytic hydrogenation. They showed weak antibiotic activities because of the changes of their steric conformation.

关 键 词：催化氢化 5′-差向庆大霉素C1a 5′-差向依替米星 抗菌活性 

分 类 号：R914.4[医药卫生—药物化学]