枝原体和尿原体对左氧氟沙星衍生物(YH7)的体外敏感性研究(英文)  

In vitro susceptibilities of Mycoplasma and Ureaplasma to a derivative (YH7) of levofloxacin

作　　者：叶辉[1] 杨玉社[2] 武济民[2] 陈凯先[2] 嵇汝运[2] 

机构地区：[1]江苏南通师范学院生命科学与技术系,南通226007 [2]中国科学院上海生命科学研究院上海药物研究所,上海200032

出　　处：《中国抗生素杂志》2002年第10期617-620,631,共5页Chinese Journal of Antibiotics

基　　金：国家自然科学基金 (№ 2 9672 0 37)资助项目

摘　　要：采用微量稀释法测定了 (S) 9 氟 2 ,3 二氢 3 甲基 10 ( 4 ( 2 嘧啶 ) 1 哌嗪基 ) 7 氧代 7H 吡啶并 [1,2 ,3 de] [1,4]苯并口恶嗪 6 羧酸 (YH 7)等氟喹诺酮及大环内酯类、四环素类抗生素对人型枝原体 (Mh)、口腔枝原体 (M .ora)、唾液枝原体 (M .sal)、解脲枝原体 (Uu)的体外敏感性。结果显示 :YH7对Mh、M .ora、M .sal、Uu的最低抑制浓度 (MIC)分别为 0 5、0 2 5、0 12 5、0 12 5mg/L。它的抑菌活性是氧氟沙星 2～ 16倍 ,与红霉素、柱晶白霉素相当。Mh、Uu对YH7及交沙霉素不易产生诱导耐药性 ,而对红霉素和四环素易产生诱导耐药性。而对红霉素或四环素产生耐药的Mh和Uu菌株对红霉素和四环素交叉耐药而对YH7和交沙霉素无交叉耐药。The in vitro susceptibilities of Mycoplasma and Ureaplasma to the derivative of levofloxacin(YH7) and referential quinolones, macrolides and tetracyclines were determined by microdilution method. Results showed that the minimum inhibition concentration (MIC) of YH7 for Ureaplasma urealyticum (Uu : 0.125 mg/L ), Mycoplasma hominis (Mh : 0.5 mg/L ), M.orale (M.ora : 0.25 mg/L ) and M.salivarium (M.sal : 0.125 mg/L ) were similar to those of macrolides (erythromyein, leucomycin) and the activity of YH7 were 2～16 folds more potent than those of ofloxacin. Uu, Mh could easily induce resistance to erythromycin and tetracycline. They did not easily produce resistance to YH7 and josamycin. Tetracycline- resistance (Tc r) or erythromycin-resistance (EM r) strains of Uu (or Mh ) had cross-resistance to erythromycin or tetracycline. However, they had no cross-resistance to YH7 and josamycin.

关 键 词：枝原体 尿原体 微生物敏感性 左氧氟沙星 YH7 

分 类 号：R969[医药卫生—药理学]