钙/钙调素依赖性蛋白激酶-Ⅱ及其生物学作用  

Calcium/calmodulin-dependent protein kinase Ⅱ and its biologic function

作　　者：王全保[1] 王建枝[2] 

机构地区：[1]山东省临沂市人民医院神经科,276003 [2]华中科技大学同济医学院,湖北武汉430030

出　　处：《中国病理生理杂志》2002年第10期1300-1302,共3页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目 (39770 175 );国家杰出青年科学基金资助项目 (3992 5 0 12 );国家重点基础研究规划 (G19990 5 4 0 0 0 )资助项目

摘　　要：Ca 2+/calmodulin-dependent protein kinase Ⅱ (CaMKⅡ) is a member of a family of Ca 2+/calmodulin-regulated protein kinases which also includes Ca 2+/calmodulin-dependent protein kinases Ⅰ and Ⅲ, myosin light chain kinases and phosphorylase kinase. Unlike the other members of this family, CaMKⅡ is multifunctional protein kinase and distributes in a variety of tissues. It is especially abundant in neuronal system. In hippocampus, CaMKⅡ is about 2% of the total protein. Studies have shown that CaMKⅡ plays an important role in a variety of biological processes, such as regulation of gene transcription, synthesis of neurotransmitter, phosphorylation of cytoskeletonal protein, hippocampal learning and memory formation.Ca 2+/calmodulin-dependent protein kinase Ⅱ (CaMKⅡ) is a member of a family of Ca 2+/calmodulin-regulated protein kinases which also includes Ca 2+/calmodulin-dependent protein kinases Ⅰ and Ⅲ, myosin light chain kinases and phosphorylase kinase. Unlike the other members of this family, CaMKⅡ is multifunctional protein kinase and distributes in a variety of tissues. It is especially abundant in neuronal system. In hippocampus, CaMKⅡ is about 2% of the total protein. Studies have shown that CaMKⅡ plays an important role in a variety of biological processes, such as regulation of gene transcription, synthesis of neurotransmitter, phosphorylation of cytoskeletonal protein, hippocampal learning and memory formation.

关 键 词：钙调蛋白 蛋白激酶Ⅱ 学习 记忆 

分 类 号：R363[医药卫生—病理学]