耳鸣机制中神经递质系统和相关调控基因的改变  

Changes of Neurotransmitter System and Related Regulatory Genes in Tinnitus Mechanism

作　　者：翟思佳 尹时华[1] ZHAI Sijia;YIN Shihua(Department of Otolaryngology&Head and Neck Surgery,Second Affiliated Hospital of Guangxi Medical University)

机构地区：[1]广西医科大学第二附属医院耳鼻咽喉头颈外科

出　　处：《中华耳科学杂志》2019年第4期572-577,共6页Chinese Journal of Otology

基　　金：广西自然科学基金周围前庭损伤所致眩晕的中枢代偿机制的实验研究(NO.2015GXNSFAA414004);广西自然科学基金膜迷路积水豚鼠三个半规管阻塞术后内耳微环境和病理生理改变的实验研究(NO.2016GXNSFAA380150)~~

摘　　要：耳鸣常因听力损失引发,其发病机制复杂多样,研究证明水杨酸钠(SS)不仅损害耳蜗功能,还影响中枢神经系统的不同部位,其中对神经递质功能的影响十分关键。本文主要阐述对N-甲基-D-门冬氨酸(NMDA)、γ-氨基丁酸(GABA)、甘氨酸能神经元等神经递质系统研究的进展现状;总结不同递质的来源分类,病变中受体通路的变化,听觉中枢调控机制,相关调控基因的改变;并展望相关研究的未来发展。Tinnitus is often caused by hearing loss.Its pathogenesis is complex and diverse.Studies have shownthat sodium salicylate not only damages cochlea function,but also affects different parts of the central nervous system.The effects on neurotransmitter function is critical.This paper mainly describes the progress of research on neurotransmittersystems such as N-methyl-D-aspartate(NMDA),γ-aminobutyric acid(GABA)and glycine-energy neurons,summarizesthe source and classification of different transmitters,changes in receptor pathways in the lesion,mechanismsof auditory central regulation,and changes in related regulatory genes,and as well as provides a vision for the future ofrelated research.

关 键 词：耳鸣 NMDA GABA 甘氨酸 

分 类 号：R764[医药卫生—耳鼻咽喉科]