补肺汤联合穴位敷贴对中晚期肺癌肺气虚证咳喘的疗效及血清炎性因子的影响  

Therapeutic effect on cough and asthma in lung cancer at the middle and late stage lung qi deficiency treated with bufei decoction and acupoint application and the impacts on serum inflammatory factor

作　　者：马红霞[1] 同立宏[1] MA Hong-xia;TONG Li-hong(Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Urumchi Xinjiang 830000)

机构地区：[1]新疆医科大学附属中医医院

出　　处：《世界中西医结合杂志》2019年第7期978-982,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：自治区卫生计生委青年科技人才专项研究项目(2015Y26)

摘　　要：目的观察补肺汤联合穴位贴敷治疗中晚期肺癌肺气虚证咳喘疗效及血清炎性因子的影响。方法将2017年1月至2018年1月期间的中晚期肺癌患者120例,随机分为治疗组和对照组,治疗组60例,对照组60例,对照组常规抗炎止咳化痰解痉平喘治疗;治疗组在对照组基础上给予补肺汤加减联合穴位敷贴治疗,连续治疗10 d后,观察两组治疗前后咳喘缓解率、咳嗽症状积分、中医证候量表评分、肺功能(FEV1及FVC用力肺活量、PEF呼气峰流速)、KPS生活质量评分、LCQ评分(莱塞斯特咳嗽生活质量)、嗜酸性粒细胞(EOS)、血清炎性因子(IL-6、IL-10)以及不良反应情况。结果治疗后,治疗组总缓解率为91.7%,对照组总缓解率为76.7%,两组比较差异有统计学意义(P<0.05)。治疗后,两组肺功能FEV1及FVC用力肺活量、PEF呼气峰流速明显改善,与治疗前比较差异有统计学意义(P<0.05);且治疗组肺功能FEV1及FVC用力肺活量、PEF呼气峰流速改善优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组咳嗽症状、中医证候量表评分、KPS评分、LCQ评分明显改善,与治疗前比较差异有统计学意义(P<0.05);且治疗组咳嗽症状、中医证候量表评分、KPS评分、LCQ评分改善优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组血清炎性因子(IL-6、IL-10)与嗜酸性粒细胞(EOS)均改善,与治疗前比较差异有统计学意义(P<0.05);且治疗组血清炎性因子(IL-6、IL-10)与嗜酸性粒细胞(EOS)改善优于对照组比较,差异有统计学意义(P<0.05)。结论补肺汤联合穴位贴敷治疗中晚期肺癌肺气虚证咳喘比单纯西医治疗效果显著,值得临床应用推广。Objective To observe the therapeutic effect on cough and asthma in lung cancer at the middle and late stage(lung qi deficiency)treated with bufei decoction and acupoint application and the impacts on serum inflammatory factor.Methods From January 2017 to January 2018,120 patients of lung cancer at the middle and late stage were randomized into a treatment group and a control group,60 cases in each one.In the control group(60 cases),the routine treatment for anti-inflammation and relieving cough,sputum,spasm and asthma was provided.In the treatment group,on the base of the treatment as the control group,the modified bufei decoction and acupoint application were supplemented.After continuous treatment for 10 days,the remission rate of cough and asthma,the score of cough symptom,the score of TCM symptom scale,lung functions(FEV1,FVC and PEF),KPS score,LCQ score,EOS,IL-6,IL-10 and adverse reactions were observed before and after treatment in the two groups.Results After treatment,the total remission rate was 91.7%in the treatment group and was 76.7%in the control group,indicating the significant difference(P<0.05).After treatment,FEV1,FVC and PEF were improved obviously,indicating the significant difference as compared with those before treatment(P<0.05).The improvements in FEV1,FVC and PEF in the treatment group were better than the control group,indicating the significant difference(P<0.05).After treatment,the score of cough symptom,the score of TCM symptom scale,KPS score and LCQ score were improved remarkably,indicating the significant difference(P<0.05).The improvements in the score of cough symptom,the score of TCM symptom scale,KPS score and LCQ score in the treatment group were better than the control group,indicating the significant differences(P<0.05).After treatment,the levels of IL-6,IL-10 and EOS were regulated,presenting the significant difference as compared with those before treatment(P<0.05).The improvements in IL-6,IL-10 and EOS were better than the control group,indicating the significant differenc

关 键 词：补肺汤 穴位贴敷 中晚期肺癌 咳喘 

分 类 号：R734.2[医药卫生—肿瘤]