胃癌相关细胞因子基因多态性的研究进展  

Progression on gene polymorphisms of gastric cancer-related cytokines

作　　者：胡滨滨 范钰[1] HU Binbin;FAN Yu(Cancer Institute,Zhenjiang First People’s Hospital,the Affiliated People’s Hospital of Jiangsu University,Zhenjiang 212002,China)

机构地区：[1]江苏大学附属人民医院镇江市第一人民医院肿瘤中心

出　　处：《临床肿瘤学杂志》2019年第7期660-664,共5页Chinese Clinical Oncology

基　　金：江苏省重点研发专项基金资助项目(BE2015666);江苏省创新团队领军人才基金资助项目(CXTDC2016006,QNRC2016446);江苏省自然科学基金资助项目(BK20171304);江苏省六大高峰人才基金资助项目(WSW-205);江苏省3333人才基金资助项目(BRA2016140)

摘　　要：世界范围内胃癌发病率及死亡率较高,且其发病机制较为复杂。环境和遗传因素是影响胃癌发生、发展的两大因素,环境因素目前已较为明朗。随着现代医学技术的发展,越来越多的研究聚焦在遗传因素,单核苷酸多态性成为热点。从基因水平研究胃癌易感性,可为胃癌预防、诊疗和预后判断提供新的依据。本文就胃癌相关细胞因子的单核苷酸多态性进行综述。Gastric cancer has a high morbidity and mortality in the world,and its pathogenesis is complicated.Environmental and genetic factors are two major factors affecting the occurrence and development of gastric cancer,and environmental factors are relatively clear at present.With the development of modern medical technology,more and more studies focus on genetic factors,and single nucleotide gene polymorphism has become a hot spot.To study the susceptibility of gastric cancer at gene level can provide a new basis for the prevention,diagnosis,treatment and prognostic evaluation of gastric cancer.This article reviews the single nucleotide polymorphism of gastric cancer-related cytokines.

关 键 词：胃癌 单核苷酸多态性(SNPs) 易感性 

分 类 号：R735.2[医药卫生—肿瘤]