手性离子液体催化苯乙烯不对称氢甲酰化反应  

Asymmetric hydroformylation of styrene catalyzed by chiral ionic liquids

作　　者：宋雅宁 吕志果[1] 郭振美[1] SONG Yaning;LU Zhiguo;GUO Zhenmei(College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,China)

机构地区：[1]青岛科技大学化工学院

出　　处：《化工科技》2019年第4期1-6,共6页Science & Technology in Chemical Industry

基　　金：国家自然科学基金项目(NSFC21376128)

摘　　要：手性是与生活休戚相关的一种自然属性,利用手性催化剂催化反应的进行是最有效的一种不对称催化合成反应方法。离子液体所具有的可设计性结构,以及黏度低、不易挥发、无异味、绿色环保等优良性质使其近年来受到化学工作者们的广泛青睐。将手性配体与功能化离子液体耦合,合成一种全新的具有不对称诱导和控制功能的手性离子液体催化剂,并用于反应考察其催化活性,得到了苯乙烯氢甲酰化的最优反应工艺条件为甲苯作溶剂,对叔丁基邻苯二酚作阻聚剂,反应温度60℃,合成气p(CO/H2)=2 MPa,n(CO)∶n(H2)=1,持续反应4 h。在该反应条件下,苯乙烯的转化率为84.9%,2-苯基丙醛收率为76%,e.e.值为84%。Chirality is one of the basic properties of the nature.Using chiral catalysts for catalytic reaction is the most effective method for asymmetric catalytic synthesis.Ionic liquids have been widely favored by chemical engineers in recent years due to their designable structure,low viscosity,non-volatile,odorless and green environmental protection.Coupling a chiral ligand to a functionalized ionic liquid,a new chiral ionic liquid catalyst with asymmetric induction and control functions was synthesized and tested for hydroformylation of styrene reaction.The optimal reaction conditions for the hydroformylation of styrene were as follows:toluene was used as the solvent;p-tert-butyl catechol was used as the polymerization inhibitor;and the reaction temperature was 60℃,and the synthesis gas[n(CO)∶n(H2)=1]pressure was 2 MPa,react time was 4 hours.Under the reaction condition,the conversion of styrene was 84.9%,the yield of 2-phenylpropanal was 76%,and the e.e.value was 84%.

关 键 词：不对称羰基化 苯乙烯 功能化手性离子液体 手性配体 手性芳基丙酸酯 氢甲酰化反应 

分 类 号：TQ032.42[化学工程]