血清miRNA-21与肾癌临床病理特征的关系及对术后复发的预测价值  

The Relationship between Serum miRNA-21 and Clinicopathological Features of Renal Cell Carcinoma and Its Predictive Value for Postoperative Recurrence

作　　者：王亚佟[1] 胡新红[1] 刘利娟 赵超群[1] WANG Yatong;HU Xinhong;LIU Lijuan(Hanzhong Central Hospital,Hanzhong,723000)

机构地区：[1]陕西省汉中市中心医院

出　　处：《实用癌症杂志》2019年第8期1249-1251,1266,共4页The Practical Journal of Cancer

摘　　要：目的探究血清miRNA-21水平与肾癌临床病理特征之间的关系及对患者术后复发的预测价值。方法选取75例肾癌患者为实验组,选取同期进行体格检查的80例健康人为健康对照组。对比术前2组研究对象血清miRNA-21水平;对比术前及术后6个月实验组患者血清miRNA-21水平,将术前实验组血清miRNA-21水平区分为高表达组(35例)和低表达组(40例),对比2组患者术后12个月的复发率。分析实验组患者血清miRNA-21水平与其病理特征之间的关系。结果(1)术前实验组患者血清miRNA-21水平高于对照组,对比差异具有统计学意义(P<0.05)。(2)术后实验组患者血清miRNA-21出现明显下调,但仍高于对照组水平,对比术前差异具有统计学意义(P<0.05)。(3)实验组血清miRNA-21高表达组患者术后12个月复发率高于低表达组,对比差异具有统计学意义(P<0.05)。(4)术前血清miRNA-21水平与肾癌患者TNM分期、浸润深度及远处转移有关(P<0.05)。结论血清miRNA-21与肾癌患者病理特征存在一定相关性,同时与肾癌的发生、发展有关,且对肾癌的复发具有一定的预测价值。Objective To explore the relationship between serum miRNA-21 level and clinicopathological characteristics of renal cell carcinoma and its predictive value for postoperative recurrence.Methods 75 cases of renal cancer treated were selected as the experimental group,and 80 healthy controls were selected.The serum levels of miRNA-21 in the 2 groups before and after the operation were compared,and the level of serum miRNA-21 in the experimental group was compared before and 6 months after the operation.The level of serum miRNA-21 was divided into high expression group(35 cases)and low expression group(40 cases),and the recurrence rate of 12 months after operation in the 2 groups was compared.Finally,the relationship between the serum miRNA-21 level and the pathological features of the patients in the experimental group was explored.Results(1)the serum miRNA-21 level of the patients in the experimental group was higher than that of the control group(P<0.05).(2)the serum miRNA-21 of the patients in the experimental group was obviously decreased,but it was still higher than the control group,and the difference was statistically significant(P<0.05),and(3)miRNA-21 in serum.The 12 month recurrence rate in the high expression group was higher than that of the low expression group,and the difference was statistically significant(P<0.05).(4)the level of serum miRNA-21 was related to the TNM stage,depth of infiltration and distant metastasis of renal cancer patients(P<0.05).Conclusion There is a certain correlation between the serum miRNA-21 and the pathological features of the patients with renal carcinoma,which is related to the occurrence and development of renal carcinoma,and has a certain predictive value for the recurrence of renal cancer.

关 键 词：血清miRNA-21 肾癌 病理特征 术后复发 预测价值 

分 类 号：R737.11[医药卫生—肿瘤]