血红素加氧酶-1在中枢神经系统疾病中的作用  

The role of heme oxygenase-1 in central nervous system diseases

作　　者：鲁玉宝 郑世敏 关心 郭星辰 马斌 董彦博 丁洋 蔡宗晏 陈昱橦 丁旭明[2] Lu Yubao;Zhen Shimin;Guan Xin;Guo Xingchen;Ma Bin;Dong Yanbo;Ding Yang;Cai Zongyan;Chen Yutong;Ding Xuming(Lanzhou University Second Hospital,Lanzhou 730030,China;Zhang Ye People’s Hospital Affiliated to Hexi University,Zhangye 73400,China)

机构地区：[1]兰州大学第二临床医学院,兰州730030 [2]河西学院附属张掖市人民医院,张掖734000

出　　处：《中国组织化学与细胞化学杂志》2019年第3期287-291,共5页Chinese Journal of Histochemistry and Cytochemistry

基　　金：兰州大学第二医院“萃英学子”科研培育计划(CYXZ-09);甘肃省高等学校科研项目(2018A-084)

摘　　要：血红素加氧酶-1(heme oxygenase-1,HO-1)是一种应激蛋白,可将血红素降解为胆绿素、游离铁和一氧化碳。目前,国内外普遍认为HO-1在神经系统损伤后的应激反应中有至关重要的作用,其表达量与神经元凋亡和神经变性密切相关。本文对近年来HO-1在神经系统损伤性疾病中的现有研究结果进行了总结分析,旨在为相关研究的发展提供新的思路和方向。Heme oxygenase-1(HO-1)acts as a 32kDa stress protein that degrades heme into biliverdin,free iron and carbon monoxide.Currently,it is widely accepted that HO-1 plays a crucial role in the stress response after nervous system injury,and its expression level is closely related to neuronal apoptosis and neurodegeneration.Therefore,this article summarizes and analyzes the research results about the role of HO-1 in nervous system injury diseases in recent years,aiming to provide new ideas and directions for the development of related researches.

关 键 词：血红素加氧酶-1 中枢神经系统疾病 帕金森症 阿兹海默症 肌萎缩侧索硬化症 

分 类 号：R363[医药卫生—病理学]