血清维生素D水平与缺血性卒中病人合并深静脉血栓的关联性研究  

Relationship between serum vitamin D level and deep vein thromboembolism in patients with ischemic stroke

作　　者：王霞[1] 陈秋菊 张文奇[1] WANG Xia;CHEN Qiu-ju;ZHANG Wen-qi(Department of Rehabilitation,Hengshui Halison International Peace Hospital,Hengshui 053000,China)

机构地区：[1]哈励逊国际和平医院康复医学科

出　　处：《实用老年医学》2019年第8期776-779,共4页Practical Geriatrics

基　　金：衡水市科学技术研究与发展计划项目(2017014045z)

摘　　要：目的本研究旨在探讨低血清25-羟基维生素D[25(OH)D]水平与缺血性卒中病人深静脉血栓的相关性。方法纳入2017年3月至2018年4月哈励逊国际和平医院康复医学科连续收治的86例缺血性卒中病人。收集年龄、性别、身高、体质量及合并疾病等信息,同时检测25(OH)D水平。根据是否合并深静脉血栓形成(DVT)分为DVT组和无DVT组,采用Logistic回归分析来明确DVT与血清25(OH)D水平的关系。结果急性缺血性脑卒中病人共23例发生DVT,DVT发生率为26.7%。DVT组和无DVT组血清25(OH)D水平、吸烟、合并高血压、糖尿病以及下肢功能不全和静脉曲张比例差异均有统计学意义。Logistic回归分析显示,维生素D缺乏、高龄、下肢功能不全、下肢静脉曲张是DVT发生的独立危险因素。结论低血清25(OH)D水平是缺血性脑卒中病人住院康复期间发生DVT的独立预测因子。25(OH)D水平降低可能在DVT发病机制中起到关键作用。Objective To determine the relationship between serum level of 25-hydroxyl vitamin D[25(OH)D]and deep vein thromboembolism(DVT)in the patients with ischemic stroke.Methods From March 2017 to April 2018,a total of 86 patients with ischemic stroke were enrolled in the department of rehabilitation of our hospital.The following demographic data including age,sex,height,weight,hypertension history,diabetes history,smoking and drinking were collected,and 25(OH)D level was detected.The patients were divided into DVT group and non-DVT group according to the results of routine dual-function imaging for the detection of DVT.Logistic regression analysis was used to explore the relationship of 25(OH)D with DVT.Results In this study,a total of 23 patients with acute ischemic stroke suffered from DVT,and the incidence rate of DVT was 26.7%.There were significant differences in the level of 25(OH)D,the rates of smoking,hypertension,diabetes,dysfunction of leg and varicosity between DVT group and non-DVT group.Logistic regression showed that 25(OH)D,age,dysfunction of leg and varicosity were independent risk factors of DVT in the patients with ischemic stroke.Conclusions Low serum level of 25(OH)D is an independent risk factor of DVT during hospitalization and rehabilitation for ischemic stroke.Those results suggest that 25(OH)D may play a key role in the pathogenesis of DVT.

关 键 词：缺血性卒中 深静脉血栓 维生素D 

分 类 号：R743.3[医药卫生—神经病学与精神病学]