短暂性全面性遗忘的临床诊治分析  

Clinical Analysis of Transient Global Amnesia

作　　者：孙金梅[1] 陈彬[1] 许春伶[1] 李尧[1] 张拥波[1] SUN Jin-mei;CHEN Bin;XU Chun-ling;LI Yao;ZHANG Yong-bo(Department of Neurology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院神经内科

出　　处：《神经损伤与功能重建》2019年第8期392-394,共3页Neural Injury and Functional Reconstruction

基　　金：国家自然科学基金（No.81801334）;首都医科大学附属北京友谊医院院启动课题（No.yyqdkt2017-13）

摘　　要：目的:总结分析短暂性全面性遗忘的危险因素、发病机制、临床表现、辅助检查及治疗方法,以其加深对该病的认识。方法:收集短暂性全面性遗忘患者15例的临床资料进行分析,并结合文献回顾。结果:15例患者中女性占66.7%;年龄56~85岁,平均年龄67.1岁;3例并发焦虑、抑郁。15例均以突发记忆丧失为主诉,同时伴随头晕、头痛等症状;3例发病前有情绪激动诱因;4例并发心率失常,脑电图均无异常尖波、棘波等;5例头颅CTA提示大脑后动脉存在变异或狭窄。全组头颅核磁均未检测到DWI异常信号。治疗上均给予抗血小板聚集、改善循环等治疗;2例复发。结论:短暂性全面性遗忘主要表现新记忆的形成障碍,是一种临床过程良性的疾病,血管因素、低灌注、情绪应激均参与该病的发病过程。Objective:To explore the clinical features,imaging manifestation,auxiliary examination,and treatment of transient global amnesia and gain deeper insight about this condition.Methods:The clinical data of 15 patients with transient global amnesia were collected and analyzed and discussed retrospectively.Results:Among the 15 patients,67%were female,and the age range was 56~85 years with an average age of 67.1 years;3 patients experienced simultaneous anxiety and depression.All 15 patients complained mainly of sudden memory loss,and this was accompanied by dizziness,headache,and other symptoms;3 patients had emotional triggers before the onset of disease;4 patients were found to have concurrent arrhythmias,and no abnormal spikes were found in the EEG.CTA of 5 patients indicated variation or narrowing of the posterior cerebral artery.No abnormal signal of DWI was detected by MRI in all patients.Antiplatelets and circulation enhancers were given to all patients,and 2 patients relapsed.Conclusion:Transient global amnesia presents mainly as the inhibition of new memory formation;it is a benign condition.Vascular factors,hypo-perfusion,and emotional stress are all involved in its pathogenesis.

关 键 词：短暂性全面性遗忘 低灌注 应激 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学]