糖皮质激素在肿瘤内科临床应用的疗效  

The Clinical Application Efficacy of Glucocorticoids in Medical Oncology

作　　者：彭宜波 PENG Yibo(Department of Ncology,Dangyang People's Hospital,Dangyang Hubei 444100,China)

机构地区：[1]湖北省当阳市人民医院肿瘤内科

出　　处：《中国继续医学教育》2019年第22期127-130,共4页China Continuing Medical Education

摘　　要：目的分析研究糖皮质激素在肿瘤内科临床应用的疗效。方法在本院收治的肿瘤内科患者中抽选150例作为本研究中的观察对象,所有患者经过简单随机分组的方式被分为低剂量组、中剂量组及高剂量组,三组患者均接受糖皮质激素进行治疗,其中低剂量组患者糖皮质激素使用剂量低于20 mg,中剂量组患者的糖皮质激素使用剂量为20~40mg,高剂量组患者使用剂量高于40 mg。对三组患者的放化疗后不良反应改善程度和不良事件发生情况进行比较。结果低剂量组和中剂量组患者的过敏反应改善率、肿瘤水肿改善率、体力改善率、放射性损伤改善率均明显较高剂量组高,其不良事件发生率明显低于高剂量组,差异有统计学意义(P<0.05);高剂量组患者的食欲改善率、恶心呕吐改善率、骨髓抑制改善率与中剂量组、低剂量组相比,差异无统计学意义(P>0.05);低剂量组患者的过敏反应改善率、肿瘤水肿改善率、体力改善率均高于中剂量组,但数据间比较差异无统计学意义(P>0.05)。结论糖皮质激素在肿瘤内科临床应用时合理调整药物使用剂量可以促进患者放化疗反应的改善,将患者的痛苦感减轻,对肿瘤临床治疗效果提升有益。Objective To study the clinical effect of glucocorticoid in oncology.Methods 150 cases of internal oncology patients in the hospital were selected as the observation objects in this study.All patients were divided into low dose group,middle dose group and high dose group by simple random grouping.All three groups were received glucocorticoid treatment,and the low dose group had low glucocorticoid dosage 20 mg,the dosage of glucocorticoid in middle dose group was 20~40 mg,and that in high dose group was higher than 40 mg.The improvement of adverse reactions and the occurrence of adverse events after radiotherapy and chemotherapy in the three groups were compared.Results The allergic reaction improvement rate,tumour edema improvement rate,physical improvement rate and radiation damage improvement rate of low-dose group and middle-dose group were signifcantly higher than those of highdose group,and the incidence of adverse events was significantly lower than that of high-dose group,the difference was statistically significant(P<0.05);tthere was no statistically significant difference in appetite improvement rate,improvement rate of nausea and vomiting,and improvement rate of myelosuppression in the high dose group compared with the middle dose group and the low dose group(P>0.05);the allergic response improvement rate, tumour edema improvement rate and physicalimprovement rate of the low dose group were higher than those of themiddle dose group, but there was no statistically significant differencebetween the data (P > 0.05). Conclusion Rational adjustment of the dosageof glucocorticoid in clinical application of oncology can improve theresponse of patients to radiotherapy and chemotherapy, alleviate the pain ofpatients, and improve the clinical therapeutic efect of tumors.

关 键 词：糖皮质激素 肿瘤内科 疗效 放化疗反应 剂量 临床应用 

分 类 号：R730[医药卫生—肿瘤]