超声波促进“一锅法”合成新型咪唑烷  

One-pot Synthesis of Novel Imidazolidines Under Ultrasonic Radiation

作　　者：高旭 杨杰 王佳楠 邓仰平 蒋小强 王世范[1] GAO Xu;YANG Jie;WANG Jia-nan;DENG Yang-ping;JIANG Xiao-qiang;WANG Shi-fan(School of Ocean,Hainan University,Haikou 570228,China)

机构地区：[1]海南大学海洋学院

出　　处：《合成化学》2019年第8期643-647,共5页Chinese Journal of Synthetic Chemistry

基　　金：海南省自然科学基金资助项目(218MS005);海南大学创新基金重点项目(Hdcxcyxm201712)

摘　　要：以芳香醛、乙二胺、丙酮和乙醛为起始原料,在超声波促进下采用一锅煮法,合成了8个咪唑烷衍生物(c1~c8,其中c3~c8为新化合物),其结构经1 H NMR,IR,MS(ESI)和XRD表征。与传统“三步加热”反应相比,微波一锅法将反应时间从2~3 h缩短至0.5 h,总收率从50%提高至80%以上。Using aromatic aldehyde,ethylenediamine,acetone and acetaldehyde as raw material,eight imidazolidine derivatives(c1~c8,c3~c8 were novel compounds)were synthesized by one pot method under ultrasonic promotion.The structures were characterized by 1 H NMR,IR,MS(ESI)and XRD.Compared with the traditional three-step heating reaction,the reaction time of one-pot method shorten from 2~3 h to 0.5 h,and the total yield increased from 50%to more than 80%.

关 键 词：咪唑烷 超声辐射 一锅煮 合成 

分 类 号：R914.5[医药卫生—药物化学] O626[医药卫生—药学]