多西他赛联合奈达铂和5-氟脲嘧啶诱导化疗后同步放化疗治疗局部晚期鼻咽癌的疗效观察  

Therapeutic effect of concurrent chemoradiotherapy after docetaxel combined with nedaplatin and 5-fluorouracil induction chemotherapy on locally advanced nasopharyngeal carcinoma

作　　者：余盈 徐祖敏 李海文 周和超 江丹贤 罗海清 YU Ying;XU Zu-min;LI Hai-wen;ZHOU He-chao;JIANG Dan-xian;LUO Hai-qing(Tumor Center,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,Guangdong,CHINA)

机构地区：[1]广东医科大学附属医院肿瘤中心

出　　处：《海南医学》2019年第16期2045-2047,共3页Hainan Medical Journal

基　　金：广东省科技计划项目(编号：20170215)

摘　　要：目的观察多西他赛联合奈达铂和5-氟脲嘧啶诱导化疗后同步放化疗治疗局部晚期鼻咽癌的疗效,为患者的临床治疗提供指导。方法选择广东医科大学附属医院肿瘤中心2015年1月至2017年1月收治的78例局部晚期鼻咽癌患者作为研究对象,按照随机数表法将患者均分为对照组和观察组各39例。对照组予以多西他赛联合奈达铂诱导化疗后同步放化疗治疗,观察组在对照组诱导化疗方案上加用5-氟脲嘧啶。治疗3个月后,比较两组患者的近期疗效及毒副反应、2年内局部控制率、无转移生存率。结果治疗3个月后,观察组患者的近期有效率为94.9%,明显高于对照组的84.6%,差异有统计学意义(P<0.05);观察组患者的毒副反应发生率为89.74%,与对照组的87.18%比较,差异无统计学意义(P>0.05);观察组患者2年内的局部控制率和无转移生存率分别为94.9%、100.0%,明显高于对照组的74.4%、92.3%,差异均有统计学意义(P<0.05)。结论多西他赛联合奈达铂和5-氟脲嘧啶诱导化疗后同步放化疗治疗局部晚期鼻咽癌近期疗效显著,而且不会明显增加毒副反应,具有临床应用价值。Objective To investigate the efficacy of concurrent chemoradiotherapy after docetaxel combined with nedaplatin and 5-fluorouracil induction chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma,and to provide guidance for clinical treatment of patients.Methods A total of 78 patients with locally advanced nasopharyngeal carcinoma were enrolled as subjects,who were admitted to the Tumor Center of the Affiliated Hospital of Guangdong Medical University from January 2015 to January 2017.The patients were divided into control group and observation group according to the random number table method.The control group received concurrent chemoradiotherapy after docetaxel combined with nedaplatin induction chemotherapy,and the observation group was additionally treated with 5-fluorouracil in the induction chemotherapy regimen of the control group.After 3 months of treatment,the short-term efficacy,toxic and side effects,local control rate within 2 years,and the non-metastatic survival rate were compared between the two groups.Results After 3 months of treatment,the short-term effective rate of the observation group was 94.9%,which was significantly higher than 84.6%of the control group,and the difference was statistically significant(P<0.05).The incidence of toxic and side effects was 89.74%in the observation group and 87.18%in the control group,and there was no significant difference between the two groups(P>0.05).The local control rate and non-metastatic survival rate of the observation group were 94.9%and 100.0%,respectively,which were significantly higher than corresponding 74.4%and 92.3%of the control group,both differences were statistically significant(P<0.05).Conclusion The short-term efficacy of concurrent chemoradiotherapy after docetaxel combined with nedaplatin and 5-fluorouracil induction chemotherapy for the treatment of locally advanced nasopharyngeal carcinoma is significant,and it does not significantly increase toxic and side effects,and has clinical application value.

关 键 词：晚期鼻咽癌 多西他赛 奈达铂 5-氟脲嘧啶 同步放化疗 疗效 毒副作用 

分 类 号：R739.63[医药卫生—肿瘤]