628例中晚期原发性肝癌患者中医证素分布特点  

Distribution characteristics of TCM syndrome elements of 628 cases primary hepatocellular carcinoma during medium and advanced stage

作　　者：邵峰[1] 曾普华[2] 曾光[1] 郜文辉[1] 贺佐梅 夏帅帅 吴华英[1] 黄惠勇[1,3] SHAO Feng;ZENG Pu-hua;ZENG Guang;GAO Wen-hui;HE Zuo-mei;XIA Shuai-shuai;WU Hua-ying;HUANG Hui-yong(Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Academy of Traditional Chinese Medicine Affiliated Hospital,Changsha 410006,China;Hunan Engineering Research Center of Anti-carcinoma Chinese Medicine,Changsha 410006,China)

机构地区：[1]湖南中医药大学,长沙410208 [2]湖南省中医药研究院附属医院,长沙410006 [3]抗肿瘤中药创制技术湖南省工程研究中心,长沙410006

出　　处：《中华中医药杂志》2019年第8期3439-3442,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金青年科学基金项目(No.81603603);抗肿瘤中药创制技术湖南省工程研究中心项目;湖南省教育厅优秀青年项目(No.14B135);湖南省科技计划项目(No.2016SK2051);湖南省自然科学基金项目(No.2016JJ4067);湖南省中医药管理局重点课题(No.201803)~~

摘　　要：目的:分析原发性肝癌病位与病性证素特点。方法:纳入湖南省中医药研究院附属医院2013年至2017年住院的原发性肝癌病历资料673份,参考《证素辨证学》的判定证素,利用文锋Ⅲ辅助诊疗系统从而分析出原发性肝癌的证素特点。使用SPSS 21.0软件,采用频次和聚类分析对证素进行处理。结果:依据纳入标准和排除标准,最终获取628份合格病历。对628份病历的证候进行逐一提取,共获得证素34个,其中病性证素19个,病位证素15个。15个病位证素中以肝出现的频率最高,其次为脾、胆、肠、胃、肺、肾、经络、心、胸膈、表、肌肤、膀胱、半表半里、神。19个病性证素中气滞出现的频率最高,其次为血瘀、气虚、湿、热、阴虚、血虚、水停、阳虚、动血、气逆、痰、食积、血热、饮、(气)闭、阳亢、气陷、不固。结论:肝、脾、胆、肠、胃是最常见的病位证素;气滞、血瘀、气虚、湿、热是最常见的病性证素,证素提取和组合规律研究补充和丰富了原发性肝癌的认识。Objective: To analyze the characteristics of disease location and disease nature syndrome elements of primary hepatocellular carcinoma. Methods: A total of 673 medical records of primary hepatocellular carcinoma from Hunan Academy of Traditional Chinese Medicine Affiliated Hospital in recent five years were collected, referring to the judgement of Syndrome Differentiation of Syndromes, and the characteristics of syndrome elements of primary hepatocellular carcinoma were analyzed by using Wenfeng III auxiliary diagnosis and treatment system. Using SPSS 21.0 software, frequency and cluster analysis were used to deal with the syndrome elements. Results: According to the inclusion criteria and exclusion criteria, 628 qualified medical records were eventually obtained. The symptoms of 628 medical records were extracted one by one. A total of34 syndrome elements were obtained, including 19 syndrome elements of disease nature and 15 syndrome elements of disease location. The highest frequency of liver appeared in 15 syndrome elements of disease location, followed by spleen, gallbladder,intestine, stomach, lung, kidney, meridian, heart, chest, diaphragm, superficies, skin, bladder, half-superficies and half-interior,and spirit. The highest frequency of qi stagnation appeared in 19 syndrome elements of disease nature, followed by blood stasis,qi deficiency, dampness, heat, yin deficiency, blood deficiency, water stopping, yang deficiency, blood activation, qireversed flow, phlegm, dyspepsia, blood heat, drinking,(qi) closure, yang hyperactivity, qicollapse, unconsolidation. Conclusion: Liver,gallbladder, spleen, stomach and kidney are the most common syndrome elements of disease location. Qi stagnation, blood stasis,qi deficiency, dampness and heat are the most common syndrome elements of disease nature. The study on the extraction and the combination of syndrome elements supplements and enrich the understanding of primary hepatocellular carcinoma.

关 键 词：原发性肝癌 证素 证型 

分 类 号：R73[医药卫生—肿瘤]