黄芩汤联合序贯肝动脉化疗栓塞术对原发性肝癌患者核因子κB及细胞缺氧诱导因子-1α的影响  

Effects of Huangqin Decoction combined with sequential hepatic arterial chemoembolization on the expression of NF-κB and HIF-1α in patients with primary liver cancer

作　　者：李岩[1] 郭鹏[2] 田月洋 LI Yan;GUO Peng;TIAN Yue-yang(Medical Department,Shandong Provincial Chest Hospital,Jinan 250013,China;Emergency Department,Eastern Hospital of Shandong Provincial Chest Hospital,Jinan 250013,China;Laboratory Department,Wuhan Central Hospital,Wuhan 430010,China)

机构地区：[1]山东省胸科医院医务科,济南250013 [2]山东省胸科医院东院急诊,济南250013 [3]武汉市中心医院检验科,武汉430010

出　　处：《中华中医药杂志》2019年第8期3870-3873,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家科技支撑计划(No.2015BAI04B10);山东省医药卫生科技发展计划(No.2015WSB23007)~~

摘　　要：目的:研究黄芩汤辅助序贯肝动脉化疗栓塞术对原发性肝癌患者核因子κB(NF-κB)及细胞缺氧有因子-1α(HIF-1α)表达的影响。方法:选取山东省胸科医院2017年1月到2018年1月原发性肝癌患者112例,采用随机数字法将其分为对照组和观察组,每组56例。两组均行肝动脉化疗栓塞术等常规治疗。观察组加口服黄芩汤辅助治疗,疗程4个月。比较两组患者的临床疗效、NF-κB、HIF-1α和甲胎蛋白(AFP)等血清含量水平。结果:观察组患者的治疗总有效率为67.86%,显著高于对照组48.21%(P<0.01)。治疗后观察组患者的NF-κB、HIF-1α水平、AFP、肿瘤体积显著低于对照组(P<0.01)。结论:黄芩汤辅助序贯肝动脉化疗栓塞术能够显著降低原发性肝癌患者NF-κB、HIF-1α含量,降低AFP表达。Objective:To study the effects of Huangqin Decoction combined with sequential hepatic arterial chemoembolization on the expression of NF-κB and HIF-1αin patients with primary liver cancer.Methods:One hundred and twelve patients with primary liver cancer admitted to our hospital from January 2017 to January 2018 were selected.They were divided into the control group and the observation group with 56 cases in each group.The patients in the two groups were treated with transcatheter hepatic arterial chemoembolization(TACE).Patients in the observation group were given oral Huangqin Decoction as adjuvant therapy on this basis.The clinical efficacy and serum levels of NF-κB,HIF-1α,and AFP were compared between the two groups.Results:The total effective rate of the observation group was 67.86%,which was significantly higher than 48.21%of the control group(P<0.01).After treatment,the levels of NF-κB,HIF-1α,the tumor volume of AFP in the observation group was significantly lower than that in the control group(P<0.01).Conclusion:Huangqin Decoction combined with sequential hepatic arterial chemoembolization can significantly reduce the content of NF-κB and HIF-1βand the expression of AFP in patients with primary liver cancer.

关 键 词：黄芩汤 肝动脉化疗栓塞术 原发性肝癌 核因子ΚB 细胞缺氧诱导因子-1α 

分 类 号：R73[医药卫生—肿瘤]