脊髓微激励信号幅值对大鼠后肢运动的调控研究  

Study on the Regulation of Spinal Cord Micro-Stimulation Signal Amplitude on Hind Limb Motion in Rats

作　　者：沈佳欢 沈晓燕[1] 马磊 陶春伶 李智玲 吕晓迎[2] 王志功[3] SHEN Jiahuan;SHEN Xiaoyan*;MA Lei;TAO Chunling;LI Zhiling;Lü Xiaoying;WANG Zhigong(School of Information Science and Technology,Nantong University,Nantong 226019,China;State Key Lab of Bioelectronics,Southeast University,Nanjing 210096,China;Institute of RF-&OE-ICs,Southeast University,Nanjing 210096,China)

机构地区：[1]南通大学信息科学技术学院,江苏南通226019 [2]东南大学生物电子学国家重点实验室,江苏南京210096 [3]东南大学射频与光电集成电路研究所,江苏南京210096

出　　处：《南通大学学报（自然科学版）》2019年第2期19-23,48,共6页Journal of Nantong University(Natural Science Edition)　

基　　金：国家自然科学基金项目(61534003,81371663);江苏省研究生科研实践创新计划项目(KYCX18_2424);南通市“226工程”科研项目;东南大学生物电子学国家重点实验室开放课题基金

摘　　要：脊髓功能电刺激能诱发因损伤或病理引起的运动功能缺损患者的肢体运动。然而,当前脊髓微激励信号参数对啮齿类动物后肢运动的调节机制尚未明确。为此,通过调节脊髓微激励信号的幅值,对大鼠后肢关节产生伸展响应和屈曲响应时各关节角度的变化值进行定量分析。实验分析表明:大鼠后肢产生伸展响应时,髋关节、膝关节与踝关节的角度变化值与刺激信号幅值的决定系数R2分别为0.58、0.87、0.74;产生屈曲响应时各关节的角度变化值与刺激信号幅值的决定系数R^2分别为0.81、0.69、0.47。研究结果表明:大鼠后肢运动的各关节角度变化值与刺激幅值具有高度相关性。大鼠后肢产生伸展响应的最佳刺激信号的幅值范围为(40±5)μA;产生屈曲响应的最佳刺激信号的幅值范围为(80±10)μA。研究结果可为进一步研制后肢步态调控用脊髓刺激器提供参考。Functional electrical stimulation can evoke limb movement in patients with motor function defect caused by injury or pathology.However,the adjustment mechanism of the micro-stimulation parameters in spinal cord on rodent hind limb movement has not been identified.Therefore,the amplitude of spinal micro-stimulation signal is adjusted and the variation value of each joint angle is selected when the hind limbs of rats produced the extension response and the flexion response.The experimental analysis reveals that the coefficient of determination(R squared)of the angle variation of each joint and stimulation signal amplitude are 0.58,0.87,0.74,respectively;and in the flexion response,the coefficient of determination(R squared)of the signal amplitude and the angle variation are 0.81,0.69,and 0.47,respectively.This indicates that the angle variation of the joints of the hind limbs of the rats is highly correlated with the stimulation amplitude. Finally, the amplitude range of the optimal stimulation signal for generating extension response of the hindlimbs of rats is determined to be 40μA±5μA and 80μA±10μA for generating flexion response. It can provide a referencefor the further development of spinal cord stimulator for the gait regulation of hind limb.

关 键 词：脊髓内微刺激 激励信号 关节角度 步态分析 

分 类 号：TP391[自动化与计算机技术—计算机应用技术] R651.2[自动化与计算机技术—计算机科学与技术]