1,25-（OH）2D3在宫颈良性病变和宫颈癌患者中的表达水平及临床意义  

Expression Level and Clinical Significance of 1,25-（OH）2D3 in Patients with Benign Cervical Lesions and Cervical Cancer

作　　者：曹蕾 上官改珍 白雯 CAO Lei;SHANGGUAN Gaizhen;BAI Wen(Laboratory Section,Air Force 986 Hospital(South Hospital),Xi'an,710054)

机构地区：[1]空军986医院(南院)

出　　处：《实用癌症杂志》2019年第9期1409-1411,共3页The Practical Journal of Cancer

摘　　要：目的研究1,25-二羟基维生素D 3(1,25-(OH)2D 3)在宫颈良性病变和宫颈癌患者中的表达水平。方法选择101例宫颈病变患者,其中55例宫颈良性病变患者为宫颈良性病变组,46例宫颈癌患者为宫颈癌组,并选择体检的35例健康女性志愿者为对照组。使用ELISA法对3组的血清1,25-(OH)2D 3水平进行检测。结果宫颈良性病变组和宫颈癌组的血清1,25-(OH)2D 3水平均明显低于对照组(P<0.05),宫颈良性病变组和宫颈癌组相比无明显差异(P>0.05)。经比较,高危宫颈癌患者血清1,25-(OH)2D 3水平明显高于低危及中危患者(P<0.05);宫颈癌患者的血清1,25-(OH)2D 3水平与绝经前后,淋巴结是否转移、组织学分级、FIGO分期及危险等级存在显著相关性(P<0.05)。结论1,25-(OH)2D 3在宫颈良性病变和宫颈癌患者中具有较低的表达水平,其水平与患者绝经前后及病理学特征存在显著相关性。Objective To study the expression level of 1,25-dihydroxy vitamin D 3(1,25-(OH)2D 3)in patients with benign cervical lesions and cervical cancer.Methods 101 cases of cervical lesions were selected,among which 55 cases of cervical benign lesions were in the cervical benign disease group,46 cases of cervical cancer were in the cervical cancer group,and 35 healthy female volunteers were selected as the control group.Serum 1,25-(OH)2D 3 levels were detected by ELISA in three groups.Results The serum level of 1,25-(OH)2D 3 in both the cervical benign disease group and the cervical cancer group was significantly lower than that in the control group(P<0.05).There was no significant difference between the cervical benign lesion group and the cervical cancer group(P>0.05);By comparison,the serum 1,25-(OH)2D 3 level of high-risk cervical cancer patients was significantly higher than that of patients with low risk(P<0.05).The serum level of 1,25-(OH)2D 3 in patients with cervical cancer was significantly correlated with lymph node metastasis,histologic grade,FIGO stage and risk level before and after menopause(P<0.05).Conclusion 1,25-(OH)2D 3 has a low expression level in patients with benign cervical lesions and cervical carcinoma,which was significantly correlated with the patient before and after menopause and pathological features.

关 键 词：1 25-二羟基维生素D 3 宫颈良性病变 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]