2D腹腔镜手术治疗结肠癌肠梗阻的临床疗效及其对炎症因子的影响  

Clinical Efficacy of Laparoscopic Operation on the Treatment of Colon Cancer and Intestinal Obstruction and Its Influences in the Inflammatory Factors

作　　者：孙洁 李冬雷 SUN Jie;LI Donglei(Tangshan Hongci Hospital,Tangshan,063000)

机构地区：[1]河北省唐山市弘慈医院,063000 [2]河北省保定市第二人民医院,071051

出　　处：《实用癌症杂志》2019年第9期1512-1514,共3页The Practical Journal of Cancer

基　　金：河北省卫生计生委科技计划项目(编号:20171062)

摘　　要：目的探讨2D腹腔镜手术治疗结肠癌肠梗阻的临床疗效及其对炎症因子的影响。方法选取结肠癌肠梗阻患者110例,按随机数字表法分为观察组和对照组,每组55例。观察组给予2D腹腔镜手术治疗,对照组给予传统开腹手术治疗。观察2组各项围术期指标和围术期并发症发生情况,观察2组治疗前后各项炎症因子变化。结果观察组手术时间、术中出血量、肛门排气时间、术后住院天数和围术期并发症发生率显著低于对照组,差异具有统计学意义(P<0.05)。治疗前,2组血清IL-6、IL-10、TNF-α和CRP水平比较,差异无统计学意义(P>0.05);治疗后,观察组血清IL-6、IL-10、TNF-α和CRP水平显著低于对照组,差异具有统计学意义(P<0.05)。结论与传统开腹手术相比,2D腹腔镜手术治疗结肠癌肠梗阻的临床疗效更优、炎症应激反应程度更低。Objective To discuss the clinical efficacy of laparoscopic operation on the treatment of colon cancer and intestinal obstruction and its influences in the inflammatory factors.Methods 110 patients with colon cancer and intestinal obstruction were selected and divided into the observation group and the control group,55 cases in each group.The observation group received laparoscopic operation treatment,the control group received open surgery treatment.The perioperative indicators and perioperative complications of the 2 groups were observed,the changes of inflammatory factors in the 2 groups before and after treatment were observed.Results Operative time,intraoperative blood loss,anal exhaust time,postoperative hospital stay and incidence of perioperative complications of the observation group was lower than the control group(P<0.05).Before treatment,serum levels of IL-6,IL-10,TNF-αand CRP,between the 2 groups had no significant difference(P>0.05);After treatment,serum levels of IL-6,IL-10,TNF-αand CRP of the observation group was lower than the control group(P<0.05).Conclusion Compared with traditional open surgery,2D laparoscopic surgery has better clinical efficacy and lower inflammatory stress response for colon cancer patients with intestinal obstruction.

关 键 词：2D腹腔镜手术 结肠癌 肠梗阻 炎症因子 

分 类 号：R735.35[医药卫生—肿瘤]