超声引导下微波消融术治疗甲状腺良性结节疗效的影响因素分析  

Analysis of Factors Influencing the Efficacy of Ultrasound-guided Microwave Ablation for Benign Thyroid Nodules

作　　者：乐飞[1] 欧阳骞[1] 李红米[1] LE Fei;OU Yangqian;LI Hongmi(Jiangxi Cancer Hospital,Nanchang,330029)

机构地区：[1]江西省肿瘤医院

出　　处：《实用癌症杂志》2019年第9期1550-1552,共3页The Practical Journal of Cancer

基　　金：江西省卫健委科技支撑项目(编号:20195435)

摘　　要：目的探讨影响超声引导下微波消融术治疗甲状腺良性结节疗效的相关因素。方法选取160例甲状腺良性结节患者作为研究对象,所有患者均接受超声引导下微波消融术治疗,治疗结束后再进行12个月的随访。根据结节缩小率将上述研究对象分为观察组(131例)与对照组(29例),观察组结节缩小率≥50%,对照组结节缩小率<50%。收集所有研究对象的临床资料,采用多因素Logistic回归模型分析影响结节缩小率的相关因素。结果①两组患者性别、年龄、体质指数(BMI),血清游离三碘甲腺原氨酸(FT3)、总三碘甲腺原氨酸(TT3),合并高血压、合并糖尿病相比差异无统计学意义(P>0.05)。观察组血清游离甲状腺素(FT4)、总甲状腺素(TT4)显著高于对照组,血清促甲状腺激素(TSH),合并肝功能损伤、合并肾功能损伤显著低于对照组,差异有统计学意义(P<0.05)。②多因素Logistic回归分析显示,血清TSH是影响超声引导下微波消融术治疗甲状腺良性结节疗效的独立危险因素,血清FT4、TT4则是其独立保护因素。结论术前检测血清FT4、TT4、TSH可以预测超声引导下微波消融术治疗甲状腺良性结节的疗效。Objective To explore the relevant factors influencing the efficacy of ultrasound-guided microwave ablation for benign thyroid nodules.Methods 160 cases of patients with benign thyroid nodule were selected as the study subjects.All patients received ultrasound-guided microwave ablation,and then were followed up for 12 months after treatment.According to the nodule shrinkage rate,these above subjects were divided into the observation group(131 cases)and the control group(29 cases),and the former was more than 50%,while the latter was less than 50%.The clinical data of all subjects were collected and the related factors affecting nodule shrinkage rate were analyzed by multivariate Logistic regression model.Results①There were no significant differences in the gender,age,body mass index(BMI),serum free triiodothyronine(FT3),serum total triiodothyronine(TT3),percentages of hypertension and diabetes mellitus between the 2 groups(P>0.05).The levels of serum free thyroxine(FT4)and total thyroxine(TT4)in observation group were significantly higher than those of the control group,while the level of serum thyroid stimulating hormone(TSH),percentages of liver function injury and renal function injury in the observation group were significantly lower than those of the control group(P<0.05).②The multivariate Logistic regression analysis showed that the serum TSH was an independent risk factor influencing the efficacy of ultrasound-guided microwave ablation for benign thyroid nodules(P<0.05),while serum FT4 and TT4 were independent protective factors(P<0.05).Conclusion Preoperative detection of serum FT4,TT4 and TSH can predict the efficacy of ultrasound-guided microwave ablation for benign thyroid nodules.

关 键 词：微波消融术 甲状腺良性结节 甲状腺素 促甲状腺激素 

分 类 号：R736.1[医药卫生—肿瘤]