胃癌根治术后感染患者Stathmin和p27与胃蛋白酶原的变化分析  

Changes of Stathmin, p27 and Pepsinogen 1 in patients with postoperative infection after radical gastrectomy

作　　者：姜伟[1] 谭志军[1] 余海峰[1] 丁文涛[1] 靳燕宇[1] 杨涛[1] JIANG Wei;TAN Zhi-jun;YU Hai-feng;DING Wen-tao;JIN Yan-yu;YANG Tao(Tianjin First Center Hospital,Tianjin 300192,China)

机构地区：[1]天津市第一中心医院普通外科

出　　处：《中华医院感染学杂志》2019年第15期2326-2329,共4页Chinese Journal of Nosocomiology

基　　金：天津市卫生局科技基金资助项目(2011KZ30)

摘　　要：目的探讨胃癌根治术后感染患者Stathmin、p27、胃蛋白酶原(Pepsinogen 1,PG1)的变化及其临床意义。方法选取2015年1月-2018年1月于天津市第一中心医院行胃癌根治术治疗且术后感染的82例患者为感染组,术后未发生感染的90例患者为非感染组。统计感染组患者感染部位和病原学结果;测定并比较两组患者Stathmin、p27、PG1水平、炎症因子水平变化。结果82例胃癌根治术后感染患者以肺部为主要感染发生部位,占36.58%,腹腔感染次之,占26.83%;82例胃癌根治术后感染患者共检出病原菌90株,其中革兰阴性菌58株占64.44%,革兰阳性菌24株占26.67%,真菌8株占8.89%;Stathmin蛋白水平在感染组患者中的表达高于对照组,p27蛋白水平在感染组患者中的表达低于对照组(P<0.001);感染组患者PG1、CRP、PCT水平高于非感染组患者(P<0.001)。结论胃癌根治术后感染能够对患者Stathmin、p27、PG1水平产生更深远的影响,同时高炎症状态亦会影响术后效果,而明确感染原因和发病机制对提高其预后效果具有重要意义。OBJECTIVE To investigate the changes of Stathmin,p27 and Pepsinogen 1(PG1)in patients with postoperative infection after radical gastrectomy.METHODS Totally 82 patients who underwent radical gastrectomy in our hospital and had postoperative infection from Jan.2015 to Jan.2018 were set as the infected group.In the same period,90 patients who were not infected after the surgery were selected as non-infected group.The infection sites and etiological results of patients in the infected group were statistically analyzed.The levels of Stathmin,p27,PG1 and inflammatory factors in the two groups were measured and compared.RESULTS Pulmonary infection was the main site of infection in the 82 patients infected after radical gastrectomy,accounting for 36.58%,followed by abdominal infection,accounting for 26.83%.A total of 90 strains of pathogens were detected in the 82 patients infected after radical gastrectomy,of which 58 were Gram-negative bacteria,24 were Gram-positive bacteria,and 8 were fungi,accounting for 64.44%,26.67%and 8.89%,respectively.The expression of Stathmin protein in the infected group was significantly higher than that in the control group,and the expression of p27 protein in the infected group was significantly lower than that in the control group(P<0.001).The levels of PG1,CRP and PCT in the infected group were significantly higher than those in the non-infected group(P<0.001).CONCLUSION Infection after radical gastrectomy can have a more profound effect on the levels of Stathmin,p27 and PG1,at the same time,the high inflammatory state will also affect the postoperative outcome.It is important to clarify the cause and pathogenesis of the infection to improve the prognosis.

关 键 词：胃癌根治术 感染 STATHMIN P27 胃蛋白酶原 

分 类 号：R619[医药卫生—外科学]