Selective O-difluoromethylation of 1,3-diones using S-(difluoromethyl) sulfonium salt  

作　　者：Guo-Kai Liu Xin Li Wen-Bing Qin Wei-Feng Lin Li-Ting Lin Jia-Yi Chen Jian-Jian Liu 

机构地区：[1]School of Pharmaceutical Sciences, Shenzhen University Health Science Centre, Shenzhen University

出　　处：《Chinese Chemical Letters》2019年第8期1515-1518,共4页中国化学快报（英文版）

基　　金：supported by the Science and Technology Foundation of Shenzhen, Shenzhen Science and Technology Innovation Committee (No. JCYJ20170818143001461)

摘　　要：A facile and highly efficient approach for selective O-difluoromethylation of 1,3-diones by recently developed bench-stable S-(difluoromethyl)sulfonium salt was described.And a broad range of difluoromthyl enol ethers were readily accessed in good to excellent yields under mild reaction conditions.Mechanistic studies revealed that the O-difluoromethylation reaction proceeds mainly via a difluorocarbene pathway.A facile and highly efficient approach for selective O-difluoromethylation of 1,3-diones by recently developed bench-stable S-(difluoromethyl)sulfonium salt was described. And a broad range of difluoromthyl enol ethers were readily accessed in good to excellent yields under mild reaction conditions. Mechanistic studies revealed that the O-difluoromethylation reaction proceeds mainly via a difluorocarbene pathway.

关 键 词：DIFLUOROCARBENE Difluoromethyl ENOL ethers 1 3-Diones O-Difluoromethylation S-(Difluoromethy)sulfonium salt 

分 类 号：O62[理学—有机化学]