Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men  

作　　者：Luca Boeri Paolo Capogrosso Eugenio Ventimiglia Filippo Pederzoli Walter Cazzaniga Francesco Chierigo Federico Deho Emanuele Montanari Francesco Montorsi Andrea Salonia 

机构地区：[1]Division of Experimental Oncology/Unit of Urology,URI,IRCCS San Raffaele Hospital,Milan 20132,Italy [2]Department of Urology,Foundation IRCCS Ca'Granda Maggiore Policlinico Hospital,University of Milan,Milan 20122,Italy [3]University Vita-Salute San Raffaele,Milan 20132,Italy

出　　处：《Asian Journal of Andrology》2019年第5期478-485,共8页亚洲男性学杂志（英文版）

摘　　要：We assessed the concomitant impact of cigarette smoking and alcohol con sumption in men presenting for primary couple's infertility.Data from 189 in fertile men were an a lyzed.Semen analysis,serum hormones,and sperm DNA fragmentation(SDF)were obtained.Smoking status was categorized as follows:current nonsmoker(-S),moderate smoker(+MS),and heavy smoker(+HS).Alcohol consumption was categorized as follows:abstainer(-D),moderate drinker(+MD),and heavy drinker(+HD).Descriptive statistics and logistic regression models were applied.Among all the participants,132(69.8%),30(15.9%),and 27(14.3%)patients were-S,+MS,and+HS,respectively.In addition,67(35.4%),77(40.7%)and 45(23.8%)men were-D,+MD and+HD,respectively.Regarding concomitant habits,52(27.5%)patients were nonsmokers and abstainers(-S/-D:Group 1),91(48.1%)had at least one recreational habit(-S/+D or+S/-D:Group 2),and 46(24.3%)were both smokers and drinkers(+S/+D:Group 3).Sperm concentration and progressive motility were lower in+HS and+HD,compared with-S and-D(all P<0.05),respectively.Similarly,both parameters were significantly lower in Group 3 than Groups 1 and 2(all P<0.05).SDF values were higher in Group 3 than Groups 1 and 2(both P<0.05).In multivariate analysis,follicle-stimulating hormone(FSH)levels and concomitant+S/+D status were independent predictors of impaired sperm concentration and progressive motility(all P<0.05).Heavy smoking and heavy drinking were associated with worse seminal parameters than moderate smoking/drinking and nonsmoking/abstaining.When concomitant,+S/+D status has an even greater detrimental effect on semen parameters.

关 键 词：ALCOHOL CON SUMPTION CIGARETTE smoki ng in FERTILITY risk factors seme n an alysis 

分 类 号：TS2[轻工技术与工程—食品科学与工程]