重建人类免疫系统的人源化小鼠模型及其在血液系统疾病研究中的应用  

Humanized Mouse Model Reconstructing Human Immune System and Its Application in Study of Blood System Diseases

作　　者：龙杰 杨志刚 LONG Jie;YANG Zhigang(Guangdong medical university,Zhanjiang 524023,China;Affiliated hospital of guangdong medical university,Zhanjiang 524001,China;Guangdong laboratory animals monitoring institute,Guangzhou 510663,China;Zhanjiang central people’s hospital affiliated to guangdong medical university,Zhanjiang 524045,China)

机构地区：[1]广东医科大学,湛江524023 [2]广东医科大学附属医院,湛江524001 [3]广东省实验动物监测所,广州510663 [4]广东医科大学附属湛江中心人民医院,湛江524045

出　　处：《实验动物科学》2019年第4期86-92,共7页Laboratory Animal Science

基　　金：广东省科技计划基金项目(No.2014A020212300; 2016A020215149);湛江市财政基金科技专项竞争性分配项目(No.2016A06003)

摘　　要：动物模型在人类疾病发病机制的研究及药理学实验研究治疗中发挥重要作用。小鼠是目前主要的实验动物,但其与人类背景存在差异,不能完全模拟人类免疫系统及疾病状态。研究人员通过将人类细胞或组织植入免疫缺陷小鼠体内,可构建免疫系统人源化小鼠模型及人源化小鼠疾病模型。人源化小鼠可通过优化人源造血干细胞来源等条件,可得到免疫系统人源化程度较高的小鼠模型。目前,GVHD人源化小鼠模型及白血病人源化小鼠模型已经应用在研究疾病发病机制及开发新型临床治疗药物等方面。Animal models play an important role in the study of human disease pathogenesis and experimental study of pharmacology.Mice are currently the main experimental animals,However,it is different from the human background,and it cannot fully simulate the human immune system and disease state.Researchers can build humanized mouse models of the immune system and humanized mouse disease models by implanting human cells or tissues into immunodeficient mice.Humanized mice can obtain a mouse model with a high degree of humanization of the immune system by optimizing conditions such as the source of human hematopoietic stem cells and other conditions.At present,the humanized mouse model of GVHD and the humanized mouse model of leukemia have been used in the study of disease pathogenesis and the development of new clinical therapeutic drugs.

关 键 词：人源化小鼠 移植物抗宿主病 白血病 动物模型 

分 类 号：R-332[医药卫生]