SOX11在胶质母细胞瘤中的表达及其临床病理学意义  

Expression and clinical pathological significance of SOX11 in glioblastoma

作　　者：吴景[1] 李晓洁[1] 何杰[1] WU Jing;LI Xiaojie;HE Jie(Department of Pathology,Anhui Provincial Cancer Hospital,Anhui Province,Hefei230031,China)

机构地区：[1]安徽省肿瘤医院病理科

出　　处：《中国医药导报》2019年第24期11-14,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81272800)

摘　　要：目的探讨SOX11在胶质母细胞瘤中的表达及其临床病理学意义。方法收集2010年9月~2017年1月安徽省立医院病理科存档的胶质母细胞瘤石蜡包埋样本264例,每例样本选取肿瘤区域及瘤旁正常脑组织制作组织芯片,采用全自动免疫组化方法检测SOX11的表达,并分析SOX11表达与患者临床病理特征的关系。结果胶质母细胞瘤中SOX11表达的总阳性率和强阳性率显著高于配对的瘤旁正常组织(P<0.01);SOX11表达与肿瘤直径、Ki67增殖指数相关(P<0.01),但其与患者年龄、性别、病灶单发/多发无关(P>0.05)。结论SOX11在胶质母细胞瘤中特异性表达,可作为胶质母细胞瘤病理诊断的标志物,其表达水平可能与肿瘤进展有关。Objective To investigate the expression and clinical pathological significance of SOX11 in glioblastoma.Methods A total of 264 cases of paraffin-embedded glioblastoma were collected from the Department of Pathology,Anhui Provincial Hospital from September 2010 to January 2017.Each sample was selected from the tumor area and the normal brain tissue of the tumor to make tissue chips.The expression of SOX11 was detected by immunohistochemistry and the relationship between SOX11 expression and clinicopathological features was analyzed.Results The total positive rate and strongly positive rate of SOX11 expression in glioblastoma was significantly higher than that in matched normal tissues of the tumor(P<0.01).The expression of SOX11 was correlated with tumor diameter and Ki67 proliferation index(P<0.01),but it was not related to the patient′s age,gender,single/multiple lesions(P>0.05).Conclusion SOX11 is specifically expressed in glioblastoma and can be used as a marker for the pathological diagnosis of glioblastoma.The expression level of SOX11 may be related to tumor progression.

关 键 词：胶质母细胞瘤 SOX11 免疫组织化学 临床病理学 诊断标志物 

分 类 号：R739.41[医药卫生—肿瘤]