MTHFR基因多态性与宫颈癌关系的Meta分析  

Meta analysis of the association between MTHFR gene polymorphisms and cervical cancer

作　　者：周青 刘帅妹 张瑞金 石慧[1] 林宁[1] 吴玉璘[1] 许豪勤 ZHOU Qing;LIU Shuaimei;ZHANG Ruijin;SHI Hui;LIN Ning;WU Yulin;XU Haoqin(Jiangsu Institute of Planned Parenthood ResearchJiangsu Clinical Laboratory of Reproductive Health,Jiangsu Province,Nanjing210036,China)

机构地区：[1]江苏省计划生育科学技术研究所江苏省生殖健康检验中心

出　　处：《中国医药导报》2019年第24期99-102,共4页China Medical Herald

基　　金：江苏省出生缺陷筛查及诊断实验室能力建设(BM2015020)

摘　　要：目的探讨亚甲基四氢叶酸还原酶基因多态性(MTHFR A1298C)与宫颈癌之间的关系,为临床提供可靠数据以便更好地预防和治疗宫颈癌。方法在万方、中国知网和PubMed等数据库检索研究MTHFR(A1298C)基因多态性与宫颈癌关系的中英文文献,检索时间为建库至2018年11月12日。通读全文最终纳入Meta分析文献共7篇,包含病例组823例和对照组1607例。应用Stata软件在5种遗传模型中分析,计算比值比(OR)和95%可信度区间(CI)评估关联度,同时进行敏感性分析以及发表偏倚的评估。结果MTHFR基因的3种模型C vs.A(OR=1.11,95%CI:1.02~1.22,P=0.015),AC vs.AA(OR=1.24,95%CI:1.02~1.52,P=0.030)和(CC+AC)vs.AA(OR=1.15,95%CI:1.03~1.29,P=0.013)均有明显相关性,提示患癌风险增加。结论MTHFR(A1298C)基因多态性可能会增加女性患宫颈癌的风险。Objective To analyze the relationship between 5,10-Methyleneterahydrofolate reductase gene polymorphisms(MTHFR A1298C)and cervical cancer in order to provide reliable data for better prevention and treatment of cervical cancer.Methods Database of Wanfang,CNKI and PubMed were searched from the time of building database to November 12,2018,and a total of 7 articles about the relationship between MTHFR gene(A1298C)polymorphisms and cervical cancer were included in this Meta-analysis,including 823 cases and 1607 controls.The odds ratio(OR)and 95%confidence interval(CI)were calculated and to assess the associations,meanwhile,the sensitivity and publication bias were analyzed.Results There were significance associations in the comparison C vs.A(OR=1.11,95%CI:1.02-1.22,P=0.015),AC vs.AA(OR=1.24,95%CI:1.02-1.52,P=0.030)and(CC+AC)vs.AA(OR=1.15,95%CI:1.03-1.29,P=0.013).Conclusion MTHFR(A1298C)gene polymorphisms may increase the risk for cervical cancer.

关 键 词：亚甲基四氢叶酸还原酶 宫颈癌 基因多态性 META分析 

分 类 号：R737.3[医药卫生—肿瘤]