胃癌组织中Podoplanin、血管内皮生长因子-C表达水平及临床意义  

Expression levels and clinical significance of podoplanin and VEGF-C in gastric cancer tissues

作　　者：唐欢 奚维东[2] 夏敏 文静 王绍荣 TANG Huan;XI Wei-dong;XIA Min;WEN Jing;WANG Shao-rong(Department of Gastroenterology,Pengzhou People's Hospital,Pengzhou 611930,China;Department of Gastroenterology,Chengdu Third People's Hospital,Chengdu 610036,China)

机构地区：[1]四川省彭州市人民医院消化内科,四川彭州611930 [2]成都市第三人民医院消化内科,四川成都610036

出　　处：《实用医院临床杂志》2019年第5期192-194,共3页Practical Journal of Clinical Medicine

摘　　要：目的探讨胃癌癌组织中Podoplanin、血管内皮生长因子(VEGF)-C表达水平及临床意义。方法127例胃癌患者,取手术切除胃癌组织(127例)及距肿瘤5~10 mm处癌旁组织(50例)石蜡标本,采用免疫组化法检测Podoplanin、VEGF-C表达水平,观察Podoplanin、VEGF-C与临床病理参数的关系。结果胃癌组织中Podoplanin、VEGF-C表达水平均高于癌旁组织(P<0.05)。不同年龄、性别、肿瘤大小的胃癌患者癌组织中Podoplanin表达水平差异无统计学意义(P>0.05),临床分期高、分化程度低、存在浆膜浸润及淋巴结转移的患者Podoplanin表达水平较高(P<0.05)。不同年龄、性别、肿瘤大小、分化程度的胃癌患者癌组织中VEGF-C表达阳性率差异无统计学意义(P>0.05),临床分期高、存在浆膜浸润及淋巴结转移患者VEGF-C表达阳性率较高(P<0.05)。结论胃癌癌组织中Podoplanin、VEGF-C表达水平较高,其中Podoplanin高表达可能与肿瘤临床分期、分化程度、浆膜浸润及淋巴结转移有关,VEGF-C表达阳性率可能与肿瘤临床分期、浆膜浸润及淋巴结转移有关。Objective To investigate the expression levels and clinical significance of podoplanin and VEGF-C in gastric cancer tissues.Methods A retrospective selection was performed on 127 patients with gastric cancer in our hospitals.The paraffin specimens of surgically resected gastric cancer tissues and adjacent tissues 5 to 10 mm away from the tumor were enrolled for study including 127 gastric cancer tissue specimens and 50 adjacent tissue specimens.The expression levels of podoplanin and VEGF-C in the samples were detected by immunohistochemistry.The expressions of podoplanin and VEGF-C in gastric cancer and adjacent tissues,and their relationship with clinicopathological parameters were observed.Results The expression levels of podoplanin and VEGF-C in gastric cancer tissues were significantly higher than those in adjacent normal tissues(P<0.05).There was no significant difference between expression levels of podoplanin in cancer tissues and age,sex or tumor size(P>0.05).The expression levels of podoplanin were increased in patients with higher clinical stage,lower differentiation degree and serosal invasion and/or lymph node metastasis(P<0.05).There was no significant difference between positive rate of VEGF-C expression in cancer tissues and age,gender,tumor size or differentiation degree(P>0.05).The positive expression rate of VEGF-C was higher in patients with higher clinical stage and serosal invasion and/or lymph node metastasis(P<0.05).Conclusion The expression levels of podoplanin and VEGF-C are relatively higher in gastric cancer tissues.The high expression of podoplanin may be related to clinical stage,differentiation degree,serosal invasion and/or lymph node metastasis.The positive rate of VEGF-C expression is related to clinical stage,serosal invasion and/or lymph node metastasis.

关 键 词：胃癌 PODOPLANIN 血管内皮生长因子C 微淋巴管密度 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]