肺癌患者血浆纤维蛋白原水平与病情分期和淋巴结转移相关  

Correlation between Plasma Fibrinogen Levels and Stage and Lymph Node Metastasis in Patients with Lung Cancer

作　　者：李丽[1] 骆益民[1] 王西华[1] 吴颖 张梅[1] Li Li;Luo Yimin;Wang Xihua;Wu Ying;Zhang Mei(Zhongda Hospital,School of Medicine,Southeast University,Nanjing,210009)

机构地区：[1]东南大学附属中大医院

出　　处：《基因组学与应用生物学》2019年第8期3760-3764,共5页Genomics and Applied Biology

摘　　要：为了探究肺癌患者血浆纤维蛋白原水平与病情分期和淋巴结转移的关系,本研究分别检测了40例肺癌患者和40例健康体检者的血浆纤维蛋白原水平,并比较了不同病理类型、病情分期、淋巴结转移与否的患者的血浆纤维蛋白原水平。研究结果显示,肺癌患者的血浆纤维蛋白原水平((4.39±0.98) g/L)明显高于健康体检者((2.74±0.48) g/L),差异具有统计学意义(p<0.05)。病情分期为Ⅰ~Ⅱ期的患者的血浆纤维蛋白原水平((4.25±1.27) g/L)明显低于Ⅲ~Ⅳ期患者((4.74±1.21) g/L),差异具有统计学意义(p<0.05)。淋巴结转移的肺癌患者的血浆纤维蛋白原水平((5.11±0.98) g/L)明显高于未淋巴结转移的患者(3.93±0.72) g/L,差异具有统计学意义(p<0.05)。本研究结果说明纤维蛋白原可能是肝癌患者高凝状态的敏感指标,可作为肝癌病情进展和预后的敏感生物标志物。To investigate the relationship between plasma fibrinogen levels and stage and lymph node metastasis in patients with lung cancer, plasma fibrinogen levels were measured in 40 lung cancer patients and 40 healthy subjects,and plasma fibrinogen levels were compared between patients with different pathological types, stage of disease,and lymph node metastasis. Studies have shown that plasma fibrinogen levels in patients with lung cancer((4.39±0.98) g/L) were significantly higher than those in healthy subjects((2.74±0.48) g/L), the difference was statistically significant(p<0.05). Plasma fibrinogen levels in patients with stage Ⅰ~Ⅱ((4.25±1.27) g/L) were significantly lower than patients with stage Ⅲ~Ⅳ((4.74±1.21) g/L) the difference was statistically significant(p<0.05). Plasma fibrinogen levels in patients with lymph node metastasis((5.11±0.98) g/L) were significantly higher than patients without lymph node metastasis((3.93±0.72) g/L), the difference was statistically significant(p<0.05). It indicates that fibrinogen may be a sensitive indicator of hypercoagulable state in patients with liver cancer. Plasma fibrinogen can be used as a sensitive biomarker for the progression and prognosis of liver cancer.

关 键 词：肺癌 纤维蛋白原 病情分期 高凝状态 淋巴结转移 

分 类 号：R73[医药卫生—肿瘤]