国内应用吉西他滨联合高强度聚焦超声治疗中晚期胰腺癌疗效的Meta分析  

Meta-analysis:clinical efficacy of gemcitabine combination with high intensity focused ultrasound in the treatment of advanced pancreatic carcinoma in China

作　　者：石乔[1] 刘垒[1] 张晓艺 荣愈平[1] 熊星铖[1] 常剑 王卫星[2] 陶京 SHI Qiao;LIU Lei;ZHANG Xiaoyi(Department of Pancreatic Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院胰腺外科,430060 [2]武汉大学人民医院肝胆外科,430060 [3]武汉大学中南医院重症医学科

出　　处：《临床外科杂志》2019年第8期680-683,共4页Journal of Clinical Surgery

基　　金：湖北省自然科学基金面上资助项目(2018CFB649);中央高校基本科研业务费专项资助项目(2042018kf0096)

摘　　要：目的通过Meta分析的方法对国内应用吉西他滨(GEM)联合高强度聚焦超声(HIFU)治疗中晚期胰腺癌(PC)疗效进行评价。方法计算机检索VIP(1989~2018年)、万方数据(1999~2018年)、CNKI(1994~2018年)、CAJD(1995~2018年)数据库中关于GEM联合HIFU治疗中晚期PC疗效的临床随机对照试验(RCT),对符合要求的RCT进行Meta分析。结果最终纳入15篇RCT,共有718例病人符合纳入标准。Meta分析结果,GEM联合HIFU治疗PC的临床有效率,临床受益率,半年生存率,1年生存率均明显高于单用GEM或HIFU治疗,且CA19-9降低更显著(P<0.05)。结论GEM联合HIFU治疗PC的疗效确切,且明显优于单用GEM或HIFU治疗。Objective To carry out a Meta-analysis on the published data in order to evaluate the clinical efficacy of gemcitabine(GEM)combination with high intensity focused ultrasound(HIFU)in the treatment of advanced pancreatic carcinoma(PC)in China.Methods A comprehensive search was performed in WANFANG(1999~2018),CAJD(1995-2018),VIP(1989~2018)and CNKI(1994~2018)databases to collect the randomized controlled trials(RCTs)which to GEM combination HIFU with in the treatment of PC,and to analyze the RCTs in Meta-analysis method.Results 718 patients were analyzed in the 15 RCTs which met the inclusion criteria.The Meta-analysis results suggested that,compared with the simple HIFU or GEM treatment group,there were higher clinical effect rates,clinical benefit rates,half one year survival rates,one year survival rates and lower levels of CA19-9 in GEM combination with HIFU treatment group(P<0.05).Conclusion The clinical efficacy of GEM combination with HIFU in the treatment of advanced pancreatic carcinoma is positive,and better than the simple GEM or HIFU treatment.

关 键 词：胰腺癌 吉西他滨 高强度聚焦超声 疗效 META分析 

分 类 号：R73[医药卫生—肿瘤]