复方麝香注射液联合高压氧治疗急性脑梗死的临床疗效及其对血清血小板第4因子、血小板α颗粒膜糖蛋白、β-血小板球蛋白水平的影响  

Clinical Effect of Compound Musk Injection Combined with Hyperbaric Oxygen Therapy on Acute Cerebral Infarction and the Impact on Serum Levels of PF4,CD62P and β-TG

作　　者：辛蓓玮 顾伟鹰[1] 时扣荣[1] 刘娟[1] 侯晓丽[1] XIN Beiwei;GU Weiying;SHI Kourong;LIU Juan;HOU Xiaoli(Department of Pharmacy,the Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China)

机构地区：[1]上海中医药大学附属上海市第七人民医院药学部

出　　处：《实用心脑肺血管病杂志》2019年第8期91-95,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的观察复方麝香注射液联合高压氧治疗急性脑梗死的临床疗效,并探讨其对血清血小板第4因子(PF4)、血小板α颗粒膜糖蛋白(CD62P)、β-血小板球蛋白(β-TG)水平的影响。方法选取2017—2018年上海中医药大学附属上海市第七人民医院收治的急性脑梗死患者112例,采用随机数字表法分为对照组和观察组,每组56例。对照组患者给予常规治疗,观察组患者在对照组基础上给予复方麝香注射液+高压氧治疗;两组患者均治疗30 d。比较两组患者临床疗效,治疗前后蒙特利尔认知评估量表(MoCA)评分、简易智力状态检查量表(MMSE)评分、Barthel指数评分及大脑中动脉血流动力学指标〔包括收缩期峰值流速(PSV)、血流速度(Vm)、搏动指数(PI)和阻力指数(RI)〕,治疗前和治疗后6个月血清PF4、CD62P、β-TG水平及血液黏度、血浆黏度、红细胞比容、纤维蛋白原,并观察治疗期间两组患者不良反应发生情况。结果(1)观察组患者临床疗效优于对照组(P<0.05)。(2)两组患者治疗前MoCA评分、MMSE评分和Barthel指数评分比较,差异无统计学意义(P>0.05);观察组患者治疗后MoCA评分、MMSE评分和Barthel指数评分高于对照组(P<0.05)。(3)两组患者治疗前大脑中动脉PSV、Vm、PI和RI比较,差异无统计学意义(P>0.05);治疗后观察组患者大脑中动脉PSV、Vm快于对照组,PI高于对照组,RI低于对照组(P<0.05)。(4)两组患者治疗前血清PF4、CD62P和β-TG水平比较,差异无统计学意义(P>0.05);观察组患者治疗后6个月血清PF4、CD62P和β-TG水平低于对照组(P<0.05)。(5)两组患者治疗前血液黏度、血浆黏度、红细胞比容、纤维蛋白原比较,差异无统计学意义(P>0.05);治疗后观察组患者血液黏度、血浆黏度、红细胞比容、纤维蛋白原低于对照组(P<0.05)。(6)两者患者治疗期间均未发生明显不良反应。结论复方麝香注射液联合高压氧治疗急性脑梗死的疗效确�Objective To observe the clinical effect of compound musk injection combined with hyperbaric oxygen therapy on acute cerebral infarction,moreover to investigate the impact on serum levels of PF4,CD62P and β-TG.Methods A total of 112 patients with acute cerebral infarction were selected in the Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from 2017 to 2018,and they were divided into control group and observation group according to random number table method,with 56 cases in each group.Patients in control group received conventional treatment,while patients in observation group received compound musk injection combined with hyperbaric oxygen therapy based on conventional treatment;both groups continuously treated for 30 days.Clinical effect,MoCA score,MMSE score,Barthel index,and hemodynamic index of middle cerebral artery(including PSV,Vm,PI and RI)before and after treatment,serum levels of PF4,CD62P and β-TG,blood viscosity,plasma viscosity,hematocrit and fibrinogen before treatment and 6 months after treatment were compared between the two groups;incidence of adverse reactions during treatment was observed.Results(1)Clinical effect in observation group was statistically significantly better than that in control group(P<0.05).(2)No statistically significant difference of MoCA score,MMSE score or Barthel index was found between the two groups before treatment(P>0.05),while MoCA score,MMSE score and Barthel index in observation group were statistically significantly higher than those in control group after treatment(P<0.05).(3)No statistically significant difference of PSV,Vm,PI or RI of middle cerebral artery was found between the two groups before treatment(P>0.05);after treatment,PSV and Vm of middle cerebral artery in observation group were statistically significantly faster than those in control group,PI of middle cerebral artery in observation group was statistically significantly higher than that in control group,while RI of middle cerebral artery in observatio

关 键 词：脑梗死 复方麝香注射液 高压氧 治疗结果 血小板第4因子 血小板α颗粒膜糖蛋白 β血小板球蛋白 

分 类 号：R743.33[医药卫生—神经病学与精神病学]