Compartmentalization of local cAMP signaling in neuronal growth and survival  

作　　者：Tomasz Boczek Michael S.Kapiloff 

机构地区：[1]Department of Ophthalmology,Byers Eye Institute,Mary M.and Sash A.Spencer Center for Vision Research,Stanford University School of Medicine,Palo Alto,CA,USA [2]Department of Molecular Neurochemistry,Medical University of Lodz,Poland

出　　处：《Neural Regeneration Research》2020年第3期453-454,共2页中国神经再生研究（英文版）

基　　金：supported in part by National Institutes of Health Grant EY026766(to MSK)

摘　　要：Intracellular signal transduction controlling neuronal development and survival is conveyed by second messengers that are often differentially regulated over space and time.The highly polarized morphology of neurons is conferred by a network of regulatory signaling pathways that determine axon guidance and dendrite formation.Among these,cyclic adenosine monophosphate(cAMP)is a second messenger that is critical for numerous neuronal functions and known to activate and integrate a variety of downstream pathways.In the central nervous system(CNS),cAMP-dependent signaling is involved in growth cone motility,neuronal metabolism,axon extension in vitro,neuroprotection,and survival in vivo.The complexity of cAMP-dependent neuronal physiology and function raises fundamental questions about the mechanisms determining the specificity by which cAMP can regulate these processes.

关 键 词：METABOLISM SPECIFICITY INTEGRATE 

分 类 号：R74[医药卫生—神经病学与精神病学]