大动脉粥样硬化型进展性脑梗死疗效的影响因素分析  

Analysis of factors influencing the efficacy of atherosclerotic progressive cerebral infarction

作　　者：涂加善[1] 刘清华[1] 林瑜 凌维汉[1] 周坤元[1] TU Jiashan;LIU Qinghua;LIN Yu;LING Weihan;ZHOU Kunyuan(Department of Neurology,Meizhou People's Hospital,Meizhou 514031,China)

机构地区：[1]梅州市人民医院神经内科

出　　处：《中国实用神经疾病杂志》2019年第9期942-947,共6页Chinese Journal of Practical Nervous Diseases

基　　金：梅州市医药卫生科研课题(编号:2017-B-33)

摘　　要：目的探讨大动脉粥样硬化型进展性脑梗死的有效治疗方法。方法纳入98例大动脉粥样硬化型进展性脑梗死患者,进行回顾性队列研究,根据患者病情进展后14 d的疗效分为有效组和无效组,分析影响疗效的治疗方法。结果多因素Logistic回归分析显示,抗凝与治疗有效相关(OR=3.640,95%CI=1.374~9.642,P=0.009);双联抗血小板聚集、高强度他汀和扩容与治疗效果不相关(P>0.05)。结论抗凝治疗对大动脉粥样硬化型进展性脑梗死有效,而双联抗血小板聚集、高强度他汀和扩容治疗效果欠佳。Objective To explore the effective treatment for progressive cerebral infarction(PCI)with large artery atherosclerosis(LAA).Methods Retrospective cohort study was conducted for 98 PCI patients with LAA.According to the treatment effect of 14 days after the worsening of the cerebral infarction,the patients were divided into effective group and ineffective group.The treatment methods were analyzed.Results As the result of multinomial logistic regression,it was found that anticoagulant was positively correlated with good outcome(OR=3.640,95%CI=1.374-9.642,P=0.009).Dual antiplatelet,intensive statin and hypervolemic treatment were not related to the therapeutic effect(P>0.05).Conclusion Anticoagulation therapy is effective for PCI with LAA,and dual antiplatelet,intensive statin and hypervolemic treatment were ineffective.

关 键 词：动脉粥样硬化 进展性脑梗死 抗凝治疗 回顾性研究 

分 类 号：R743.33[医药卫生—神经病学与精神病学]