慢性炎症性脱髓鞘性多发性神经病的神经系统康复和治疗  

Nervous system rehabilitation of chronic inflammatory demyelinating polyneuropathy patients

作　　者：车文生[1] 蔡琛[1] CHE Wensheng;CAI Chen(Department of Rehabilitation Medicine,People's Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州人民医院康复医学科

出　　处：《中国实用神经疾病杂志》2019年第9期976-980,共5页Chinese Journal of Practical Nervous Diseases

基　　金：河南省科技攻关项目(编号:182102310537)

摘　　要：目的分析慢性炎症性脱髓鞘性多发性神经病(CIDP)的神经系统的康复和治疗效果。方法收集郑州人民医院神经内科和康复科2016-01—2018-05收治的108例CIDP患者,随机分成观察组58例和对照组50例,均采用激素治疗,其中对照组实施康复科常规康复措施,观察组采用系统康复治疗,对比2组治疗前后的临床表现、不良反应、实验室检查及病理检查结果。结果治疗后观察组总显效率显著高于对照组(P<0.05),不良反应发生率显著低于对照组(P<0.05);观察组脑脊液检测及神经电生理检测与对照组相比,脑脊液细胞数、SCV减慢及F波潜伏期延长或消失差异有统计学意义(P<0.05),其余纳入指标差异无统计学意义(P>0.05);观察组病理检查的总异常率显著低于对照组(P<0.05)。结论对CIDP患者采取系统康复与治疗能够有效提高临床疗效,降低并发症的发生率,改善临床实验室检测指标。Objective To investigate the rehabilitation of nervous system of chronic inflammatory demyelinating polyneuropathy(CIDP)patients.Methods A total of 108 subjects with CIDP were enrolled in the Department of Neurology and Rehabilitation in January 2016 and May 2018 in People's Hospital of Zhengzhou.They were randomly divided into observation group and controls according to the principle of averaging.The patients in each group received hormone therapy.Among them,the control group received routine rehabilitation measures,while observation group used rehabilitation and treatment.The clinical manifestations and significant efficiencies before and after treatment were compared between the two groups of patients.Results After treatment,total remission rate of CIDP patients in observation group was significantly higher than controls(P<0.05);the incidence of clinical adverse reactions in observation group was significantly lower than in control(P<0.05);the laboratory examination of observation group included cerebrospinal fluid test,neuroelectrophysiological test.There was significant difference in some indexes including the number of cerebrospinal fluid cells,SCV,slowing down and prolonging or disappearing of F wave latency(P<0.05),but there was no significant difference in other indexes.The total abnormal rate of pathological examination in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Systematic rehabilitation and treatment for patients with CIDP can effectively improve the clinical efficacy,reduce the incidence of complications,improve clinical laboratory testing indicators,promote rehabilitation,which is worthy of clinical promotion.

关 键 词：慢性炎性脱髓鞘性多发性神经根神经病 自身免疫性疾病 系统康复 神经系统 

分 类 号：R744.5[医药卫生—神经病学与精神病学]