Digital biomanufacturing supporting vascularization in 3D bioprinting  

作　　者：William Whitford James B.Hoying 

机构地区：[1]BioProcess,GE Healthcare Life Sciences,925 West 1800 South,Logan,UT 84321,USA [2]Advanced Solutions Life Sciences,1901 Nelson Miller Parkway,Louisville,KY 40223,USA

出　　处：《International Journal of Bioprinting》2017年第1期18-26,共9页国际生物打印期刊

摘　　要：Synergies in bioprinting are appearing from individual researchers focusing on divergent aspects of the technology.Many are now evolving from simple mono-dimensional operations to model-controlled multi-material,interpenetrating networks using multi-modal deposition techniques.Bioinks are being designed to address numerous critical process parameters.Both the cellular constructs and architectural design for the necessary vascular component in digitally biomanufactured tissue constructs are being addressed.Advances are occurring from the topology of the circuits to the source of the of the biological microvessel components.Instruments monitoring and control of these activates are becoming interconnected.More and higher quality data are being collected and analysis is becoming richer.Information management and model generation is now describing a“process network.”This is promising;more efficient use of both locally and imported raw data supporting accelerated strategic as well as tactical decision making.This allows real time optimization of the immediate bioprinting bioprocess based on such high value criteria as instantaneous progress assessment and comparison to previous activities.Finally,operations up-and down-stream of the deposition are being included in a supervisory enterprise control.

关 键 词：DIGITAL biomanufacturing BIOPRINTING VASCULOGENESIS microvasculatures bioinks 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]