衰老动物模型及其研究进展  

Research progress in aging animal models

作　　者：卢延华 管博文 孟爱民 LU Yanhua;GUAN Bowen;MENG Aimin(Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences(CAMS),Comparative Medicine Center,Peking Union Medical College(PUMC),NHC Key Laboratory of Human Disease Comparative Medicine,Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Beijing 100021,China)

机构地区：[1]中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病比较医学重点实验室,北京市人类重大疾病实验动物模型工程技术研究中心,北京100021

出　　处：《中国比较医学杂志》2019年第9期109-113,共5页Chinese Journal of Comparative Medicine

基　　金：中国医学科学院医学与健康科技创新工程经费资助(2017-I2M-3-015);国家重点研发计划(2017YFA0105204);国家自然科学基金(81573094)。

摘　　要：衰老是生物体的必然结局。延缓衰老延长寿命、减少老年病改善老年人生活质量一直是人们的研究热点。构建衰老动物模型,使实验动物呈现与人类相似的衰老表型,是研究人类衰老机制和研发抗衰老药物的重要手段。目前广泛应用的衰老模型,涵盖了从果蝇、线虫等无脊椎动物,到小型鱼类、啮齿动物和非人灵长类等等。近年来,各种基因修饰小鼠在研究衰老发生、发展及干预评价中起到重要作用;另外在常规模式动物之外,选用寿命不同的生物以及寿命差异较大的同一物种,进行寿命相关生物学分析也为研究衰老提供了新的手段。由于衰老是复杂的生物学过程,影响因素多,只有充分进行比较医学研究才能更好地将研究成果转化,为人类健康老年提供保障。Aging is an inevitable outcome for all organisms.Researchers are exploring how to delay senescence and reduce the incidences of age-related diseases,prolong life-span and improve the quality of life in old age.Establishing aging animal models that show aging phenotypes similar to those of humans is an effective way to explore the mechanisms of human aging and research of anti-aging drugs.There are various animal models,such as nematodes,rodents and primates.In recent years,different types of genetically modified mice have emerged.At the same time,researchers have started to use animal models with different life-spans to conduct comparative studies.As aging is a complex biological process with many influencing factors,only by conducting fully comparative medical research can we better transform the research results of aging and guarantee healthier aging of human beings.

关 键 词：衰老 动物模型 比较医学 

分 类 号：R-33[医药卫生]