左旋多巴联用普拉克索治疗原发性不宁腿综合征的疗效观察  

Effects of Pramipexole Combined with L-dopa on Patients with Idiopathic Restless Legs Syndrome

作　　者：王珲 谭向红 陈艳香 唐荣华[2] WANG Hui;TAN Xiang-hong;CHEN Yan-xiang;TANG Rong-hua(Department of Neurology,Affiliated Xiaolan Hospital affiliated to Southern Medical University,Guangdong 528415,China;Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]南方医科大学附属小榄医院神经内科,广东小榄528415 [2]华中科技大学同济医学院附属同济医院神经内科,武汉430030

出　　处：《神经损伤与功能重建》2019年第9期441-443,共3页Neural Injury and Functional Reconstruction

摘　　要：目的:观察左旋多巴联合应用普拉克索对原发性不宁腿综合征(RLS)患者的疗效。方法:中~重度原发性RLS患者30例,随机分为对照组和联合组各15例,2组均予普拉克索0.25~0.75 mg/d,联合组还予美多巴62.5~125 mg/d,治疗6周。利用RLS严重程度量表(IRLS)、临床总体印象改善量表(CGI-I)、患者总体印象量表(PGI)和Epworth嗜睡量表(ESS)评估患者治疗前后的RLS症状严重程度和嗜睡程度,同时记录不良反应。结果:2组治疗后IRLS评分均低于治疗前(P<0.05);联合组治疗后的IRLS评分低于对照组(P<0.05)。治疗后,联合组的CGI-I及PGI评估显效率高于普拉克索组(P<0.05)。2组治疗后ESS评分均低于治疗前(P<0.05),2组治疗后的ESS评分差异无统计学意义(P>0.05)。结论:左旋多巴联合应用普拉克索对原发性RLS的疗效优于单用普拉克索。Objective:To demonstrate the efficacy of pramipexole combined with L-dopa on patients with idiopathic restless legs syndrome(RLS).Methods:Thirty patients with moderate to severe RLS were randomly divided into the control group and combined group with 15 patients in each.During the 6 weeks of treatment,both groups were given Pramipexole(0.25~0.75 mg/d),and the combined group was additionally given Madopar(62.5~125 mg/d).The international RLS scale(IRLS),patient global impression(PGI)scale,clinical global impressions-improvement(CGI-I)scale,and Epworth sleepiness scale(ESS)were used to evaluate RLS symptom severity and sleepiness before and after treatment;incidence of adverse events was also recorded throughout the trial.Results:IRLS scores decreased after therapy both in both groups(P<0.05),and the post-treatment IRLS score in the combined group was lower than that in the control group(P<0.05).After therapy,CGI-I and PGI scores of the combined group were significantly greater than that in the control group(P<0.05).ESS scores decreased after therapy in both groups(P<0.05),and there was no statistical difference between the post-treatment ESS scores of the two groups(P>0.05).Conclusion:The efficacy of pramipexole combined with L-dopa in the treatment of idiopathic RLS is greater than that of pramipexole alone.

关 键 词：原发性不宁腿综合征 左旋多巴 普拉克索 

分 类 号：R741[医药卫生—神经病学与精神病学] R742.5[医药卫生—临床医学]