对比分析青年及中老年乳腺癌患者临床病理特征及免疫组化特点  

Comparative analysis of clinicopathological features and immunohistochemical characteristics of young and middle-aged patients with breast cancer

作　　者：宋美英 王玲 张财家 徐艳 Song Meiying;Wang Ling;Zhang Caijia;Xu Yan(Department of Pathology,First People's Hospital of Jinzhou District,Dalian,Liaoning,116100,China)

机构地区：[1]大连市金州区第一人民医院病理科

出　　处：《当代医学》2019年第28期80-82,共3页Contemporary Medicine

摘　　要：目的对青年以及中老年乳腺癌患者的临床病理特征进行对比研究,同时分析其免疫组化特点。方法选取2014年1月至2018年12月,到本院进行治疗的136例乳腺癌患者作为研究对象,将其分为青年组58例及老年组78例,进行病理学检查及免疫组化分析。结果两组患者的肿瘤最大径、发病部位、组织学分类比较差异均无统计学意义;青年组病灶多发,组织学分级多为Ⅲ级,老年组病灶单发,组织学分级为Ⅱ级,差异具有统计学意义(P<0.05),青年组患者的肿瘤病理分期主要为Ⅱ~Ⅲ期(82.76%),中老年组患者的肿瘤分期主要为Ⅰ~Ⅱ期(73.08%),差异具有统计学意义(P<0.05);青年组患者的ER(+)、PR(+)比例均低于中老年组患者,C-erbB-2(+)比例、Ki-67>30%比例高于中老年组患者(P<0.05)。结论青年乳腺癌患者肿瘤多发,组织学分级较高,病理分期更高,且C-erbB-2阳性率、Ki-67表达指数较高,ER、PR阳性率较低。Objective To compare the clinicopathological features of young and middle-aged breast cancer patients,and to analyze their immunohistochemical characteristics.Methods A total of 136 breast cancer patients who underwent treatment in our hospital from January 2014 to February 2018 were enrolled in the study.They were divided into a young group of 58 patients and an elderly group of 78 patients for pathological examination and immunohistochemistryanalysis.Results There were no significant differences in the maximum diameter,location,and histological classification between the two groups.The lesions in the young group were multiple,the histological grade was mostly gradeⅢ,and the lesions in the elderly group were single,and the histological was gradeⅡ.The grades were significantly different(P<0.05).The tumor pathological stage of the young group was mainly stageⅡ-Ⅲ(82.76%).The tumor stage of the middle-aged group was mainly stageⅠ-Ⅱ(73.08%),and the difference was significant(P<0.05);the proportion of ER(+)and PR(+)in the young group was lower than that in the middle-aged group,and the ratio of C-erbB-2(+)and Ki-67>30%was higher than that of the middle-aged group(P<0.05).Conclusion Young breast cancer patients have multiple tumors,high histological grade,higher pathological stage,and higher C-erbB-2 positive rate and Ki-67 expression index,and lower ER and PR positive rates.

关 键 词：青年 中老年 乳腺癌 临床病理 免疫组化 

分 类 号：R73[医药卫生—肿瘤]