Foxp3 β-catenin在乳腺癌组织中的表达及其与临床预后的关系  

Expression of Foxp3 and beta-catenin in Breast Cancer and the Relationship with Clinical Prognosis

作　　者：李骏 郎晓讴[1] LI Jun;LANG Xiao'ou(The Central Hospital Affiliated to Shenyang Medical College,Liaoning Shenyang 110024,China)

机构地区：[1]沈阳医学院附属中心医院普外科

出　　处：《河北医学》2019年第9期1470-1473,共4页Hebei Medicine

摘　　要：目的:探讨叉头状/翼状螺旋转录因(Foxp3)、β-连环蛋白(β-catenin)在乳腺癌组织中的表达及其与临床预后的关系。方法:选取2016年8月至2018年8月本院乳腺癌及其癌旁正常组织80例,采用免疫组织化学法检测组织中Foxp3、β-catenin表达情况,分析二者与乳腺癌病理特征及生存预后的关系。结果:乳腺癌组织中Foxp3、β-catenin表达阳性率明显高于癌旁正常组织,差异有统计学意义(P<0.05);乳腺癌组织中Foxp3、β-catenin表达与临床分期、病理分级、淋巴结转移有关(P<0.05);乳腺癌组织中Foxp3与β-catenin表达呈正相关(P<0.05);生存曲线分析显示,Foxp3、β-catenin表达阳性者1年生存率明显低于Foxp3、β-catenin表达阴性者,差异有统计学意义(P<0.05)。结论:Foxp3、β-catenin与乳腺癌的发生发展有关,二者表达呈正相关,提示检测二者表达可作为评估乳腺癌临床预后的重要指标。Objective:To discuss the expression of forked head/wing like spiral transcription factor(Foxp3)and beta catenin in breast cancer and the relationship with clinical prognosis.Methods:The expression of Foxp3 and beta-catenin in 80 cases of breast cancer and adjacent normal tissues in our hospital from August 2016 to August 2018 was detected by immunohistochemistry.The relationship between the expression of Foxp3 and beta-catenin and pathological characteristics and survival and prognosis of breast cancer was analyzed.Results:The positive rates of Foxp3 and beta-catenin expression in breast cancer tissues were significantly higher than those in adjacent normal tissues,the difference was statistically significant(P<0.05).The expressions of Foxp3 and beta-catenin in breast cancer tissues were correlated with clinical stage,pathological grade and lymph node metastasis(P<0.05).The expressions of Foxp3 and beta-catenin in breast cancer tissues were positively correlated(P<0.05).The survival curve analysis showed that,the 1-year survival rate of patients with positive expression of Foxp3 and beta-catenin was significantly lower than those patients with with negative expression of Foxp3 and beta-catenin,the difference was statistically significant(P<0.05).Conclusions:Foxp3 and beta-catenin are related to the occurrence and development of breast cancer,and their expressions are positively correlated,suggesting that the detection of their expressions can be used as the important index for evaluating the clinical prognosis of breast cancer.

关 键 词：叉头状/翼状螺旋转录因 Β-连环蛋白 乳腺癌 

分 类 号：R73[医药卫生—肿瘤]